PDF(Pubmed)
Abstract：
The brain derived-neurotrophic factor (BDNF) Val66Met polymorphism causes functional changes in BDNF, and is associated with obesity and some psychiatric disorders, but its relationship to health-related quality of life (HRQoL) remains unknown. This study examined, in youth with obesity, whether carriers of the BDNF Val66met polymorphism Met-alleles (A/A or G/A) differed from noncarriers (G/G) on HRQoL. The participants were 187 adolescents with obesity. Ninety-nine youth were carriers of the homozygous Val/Val (G/G) alleles, and 88 were carriers of the Val/Met (G/A) or Met/Met (A/A) alleles. Blood samples were drawn in the morning after an overnight fast for genotyping. HRQoL was measured using the Pediatric-Quality of Life core version. Compared to carriers of the Val66Met Val (G/G) alleles, carriers of the Met-Alleles reported significantly higher physical -HRQoL (p = 0.02), school-related HRQoL, (p = 0.05), social-related HRQoL (p = 0.05), and total HRQoL (p = 0.03), and a trend for Psychosocial-HRQoL. Research is needed to confirm our findings and determine whether carriers of the BDNF Val66Met homozygous Val (G/G) alleles may be at risk of diminished HRQoL, information that can influence interventions in a high-risk population of inactive youth with obesity.
摘要：
脑源性神经营养因子（BDNF）Val66Met多态性引起BDNF的功能变化，与肥胖和一些精神疾病有关，但其与健康相关生活质量(HRQoL)的关系尚不清楚.这项研究检查了，在肥胖的年轻人中，BDNFVal66met多态性Met等位基因（A/A或G/A）的携带者在HRQoL上是否与非携带者（G/G）不同。参与者是187名肥胖青少年。99名青年是纯合Val/Val（G/G）等位基因的携带者，和88个是Val/Met(G/A)或Met/Met(A/A)等位基因的携带者。在禁食过夜后的早晨抽取血样用于基因分型。使用儿科生活质量核心版本测量HRQoL。与Val66MetVal（G/G）等位基因的携带者相比，Met等位基因的携带者报告了显着更高的身体-HRQoL（p=0.02），学校相关的HRQoL，（p=0.05），社会相关HRQoL(p=0.05)，和总HRQoL(p=0.03)，和心理社会HRQoL的趋势。需要研究来证实我们的发现，并确定BDNFVal66Met纯合Val（G/G）等位基因的携带者是否有HRQoL降低的风险，可能影响肥胖不活跃青年高危人群干预措施的信息。
