%0 Journal Article
%T The BDNF Val66Met polymorphism and health-related quality of life in youth with obesity.
%A Goldfield GS
%A Cameron JD
%A Sigal RJ
%A Kenny GP
%A Prud'homme D
%A Ngu M
%A Alberga AS
%A Doucette S
%A Goldfield DB
%A Tulloch H
%A Thai H
%A Simas KR
%A Walsh J
%J Physiol Rep
%V 12
%N 13
%D 2024 Jul
%M 38997217
暂无%R 10.14814/phy2.16140
%X The brain derived-neurotrophic factor (BDNF) Val66Met polymorphism causes functional changes in BDNF, and is associated with obesity and some psychiatric disorders, but its relationship to health-related quality of life (HRQoL) remains unknown. This study examined, in youth with obesity, whether carriers of the BDNF Val66met polymorphism Met-alleles (A/A or G/A) differed from noncarriers (G/G) on HRQoL. The participants were 187 adolescents with obesity. Ninety-nine youth were carriers of the homozygous Val/Val (G/G) alleles, and 88 were carriers of the Val/Met (G/A) or Met/Met (A/A) alleles. Blood samples were drawn in the morning after an overnight fast for genotyping. HRQoL was measured using the Pediatric-Quality of Life core version. Compared to carriers of the Val66Met Val (G/G) alleles, carriers of the Met-Alleles reported significantly higher physical -HRQoL (p = 0.02), school-related HRQoL, (p = 0.05), social-related HRQoL (p = 0.05), and total HRQoL (p = 0.03), and a trend for Psychosocial-HRQoL. Research is needed to confirm our findings and determine whether carriers of the BDNF Val66Met homozygous Val (G/G) alleles may be at risk of diminished HRQoL, information that can influence interventions in a high-risk population of inactive youth with obesity.