Abstract：
In this study, we developed an effective method for the large-scale synthesis of chenodeoxycholic acid (CDCA) from phocaecholic acid (PhCA). A high total yield of up to 72 % was obtained via five steps including methyl esterification, Ts-protection, bromination, reduction, and hydrolysis. The structures of the intermediates were confirmed by 1H NMR (Nuclear Magnetic Resonance), 13C NMR, HRMS (High Resolution Mass Spectrometry), and IR (Infrared Spectroscopy) spectroscopies. This method offers a new and practical approach to the synthesizing of CDCA.
摘要：
在这项研究中,我们开发了一种有效的方法来大规模合成鹅去氧胆酸（CDCA）从佛果胆酸（PhCA）。通过包括甲酯化在内的五个步骤获得高达72％的高总收率，Ts保护,溴化,reduction,和水解。中间体的结构通过1HNMR（核磁共振）证实，13CNMR,HRMS（高分辨率质谱），和IR（红外光谱）光谱。该方法为CDCA的合成提供了一种新的实用方法。
