{Reference Type}: Journal Article
{Title}: Practical synthesis of chenodeoxycholic acid from phocaecholic acid.
{Author}: He Z;Liang N;Zou S;Yu F;Zeng Y;Chen X;Wang Y;Zhou L;Wang Q;
{Journal}: Steroids
{Volume}: 209
{Issue}: 0
{Year}: 2024 Sep 10
{Factor}: 2.76
{DOI}: 10.1016/j.steroids.2024.109470
{Abstract}: In this study, we developed an effective method for the large-scale synthesis of chenodeoxycholic acid (CDCA) from phocaecholic acid (PhCA). A high total yield of up to 72 % was obtained via five steps including methyl esterification, Ts-protection, bromination, reduction, and hydrolysis. The structures of the intermediates were confirmed by 1H NMR (Nuclear Magnetic Resonance), 13C NMR, HRMS (High Resolution Mass Spectrometry), and IR (Infrared Spectroscopy) spectroscopies. This method offers a new and practical approach to the synthesizing of CDCA.