PDF(Pubmed)
Abstract：
Few T cells infiltrate into primary brain tumors, fundamentally hampering the effectiveness of immunotherapy. We hypothesized that Toxoplasma gondii, a microorganism that naturally elicits a Th1 response in the brain, can promote T cell infiltration into brain tumors despite their immune suppressive microenvironment. Using a mouse genetic model for medulloblastoma, we found that T. gondii infection induced the infiltration of activatable T cells into the tumor mass and led to myeloid cell reprogramming toward a T cell-supportive state, without causing severe health issues in mice. The study provides a concrete foundation for future studies to take advantage of the immune modulatory capacity of T. gondii to facilitate brain tumor immunotherapy.
摘要：
很少有T细胞渗入原发性脑肿瘤，从根本上阻碍了免疫疗法的有效性。我们假设弓形虫,一种在大脑中自然引发Th1反应的微生物，尽管它们具有免疫抑制的微环境，但可以促进T细胞浸润到脑肿瘤中。使用髓母细胞瘤的小鼠遗传模型，我们发现弓形虫感染诱导可激活的T细胞浸润到肿瘤块中，并导致骨髓细胞向T细胞支持状态重编程，不会对老鼠造成严重的健康问题。该研究为未来的研究提供了具体的基础，以利用弓形虫的免疫调节能力来促进脑肿瘤的免疫治疗。
