METHODS: This retrospective study analyzed 11 cases of intracranial SFTs treated at a neurosurgical centre in India between February 2020 and January 2024. Clinical data, radiological findings, histopathological features, and follow-up details were reviewed. Immunohistochemistry, particularly STAT6, facilitated diagnosis confirmation.
RESULTS: The median age of presentation was 32 years, with a male predominance. Headache was the most common presenting symptom, often leading to misdiagnosis as meningiomas on radiological imaging. Histologically, SFTs exhibited spindle to ovoid cells with staghorn vessels and collagenized stroma, posing challenges in differential diagnosis. WHO grading predominantly revealed grade 1 tumors, though recurrence occurred, emphasizing the importance of long-term follow-up. Immunohistochemistry, particularly STAT6, played a pivotal role in distinguishing SFTs from other entities.
CONCLUSIONS: Intracranial SFTs present diagnostic challenges due to overlapping features with other tumors, warranting a comprehensive approach integrating clinical, radiological, and histopathological findings. Immunohistochemistry, particularly STAT6, emerges as a valuable diagnostic tool. Long-term follow-up is essential for monitoring recurrence and potential malignant transformation. Further research is needed to delineate optimal treatment strategies, including the role of radiotherapy in SFT management.
方法:这项回顾性研究分析了2020年2月至2024年1月在印度神经外科中心治疗的11例颅内SFT。临床数据,放射学发现,组织病理学特征,和随访细节进行了审查。免疫组织化学,特别是STAT6,促进诊断确认。
结果:就诊年龄中位数为32岁,男性占主导地位。头痛是最常见的症状,常导致影像学误诊为脑膜瘤。组织学上,SFT表现为梭形至卵形细胞,鹿角状血管和胶原基质,在鉴别诊断中提出了挑战。WHO分级主要显示1级肿瘤,虽然复发,强调长期跟进的重要性。免疫组织化学,特别是STAT6,在区分SFT与其他实体方面发挥了关键作用。
结论:颅内SFT由于与其他肿瘤的重叠特征而存在诊断挑战,保证一个综合的方法,整合临床,放射学,和组织病理学发现。免疫组织化学,特别是STAT6,成为一种有价值的诊断工具。长期随访对于监测复发和潜在的恶性转化至关重要。需要进一步的研究来描述最佳的治疗策略,包括放疗在SFT管理中的作用。