Abstract：
OBJECTIVE: Comparing the utility of the anti-human serum amyloid A (SAA)-specific monoclonal and polyclonal antibodies assays (LZ-SAA) with the pure monoclonal anti-human antibody assays (VET-SAA) during clinical practice in primary care hospital populations by measuring SAA measurement in healthy and diseased domestic cats.
METHODS: 52 healthy and 185 diseased client-owned cats.
METHODS: SAA concentration was measured using different LZ-SAA and VET-SAA measurements for healthy and various diseased cats. Sensitivity, specificity, and accuracy were calculated for each disease.
RESULTS: VET-SAA has higher sensitivity than LZ-SAA for the most common diseases presenting to primary care veterinary hospitals, including chronic kidney disease, tumors, and gingivostomatitis. Our results reveal the capability of detecting low SAA concentrations in healthy and diseased cats using VET-SAA in contrast to LZ-SAA, which found elevations of SAA concentrations only in diseased cats.
CONCLUSIONS: Our findings indicate that switching to the new VET-SAA instead of the conventional LZ-SAA will likely enhance the diagnostic performance in primary care veterinary hospitals.
METHODS: 52 healthy and 185 diseased client-owned cats.
METHODS: SAA concentration was measured using different LZ-SAA and VET-SAA measurements for healthy and various diseased cats. Sensitivity, specificity, and accuracy were calculated for each disease.
RESULTS: VET-SAA has higher sensitivity than LZ-SAA for the most common diseases presenting to primary care veterinary hospitals, including chronic kidney disease, tumors, and gingivostomatitis. Our results reveal the capability of detecting low SAA concentrations in healthy and diseased cats using VET-SAA in contrast to LZ-SAA, which found elevations of SAA concentrations only in diseased cats.
CONCLUSIONS: Our findings indicate that switching to the new VET-SAA instead of the conventional LZ-SAA will likely enhance the diagnostic performance in primary care veterinary hospitals.
摘要：
目的：比较抗人血清淀粉样蛋白A（SAA）特异性单克隆和多克隆抗体测定（LZ-SAA）与纯单克隆抗人抗体测定（VET-SAA）的效用。通过测量健康和患病家猫的SAA测量，在初级保健医院人群的临床实践中。
方法：52只健康猫和185只患病猫。
方法:对于健康和各种患病猫,使用不同的LZ-SAA和VET-SAA测量来测量SAA浓度。灵敏度,特异性，并计算每种疾病的准确性。
结果：VET-SAA比LZ-SAA对初级保健兽医医院最常见的疾病具有更高的敏感性，包括慢性肾病,肿瘤，和牙龈炎.我们的结果揭示了与LZ-SAA相比，使用VET-SAA在健康和患病猫中检测低SAA浓度的能力，仅在患病的猫中发现SAA浓度升高。
结论：我们的研究结果表明，改用新的VET-SAA而不是传统的LZ-SAA可能会提高初级保健兽医医院的诊断性能。
方法：52只健康猫和185只患病猫。
方法:对于健康和各种患病猫,使用不同的LZ-SAA和VET-SAA测量来测量SAA浓度。灵敏度,特异性，并计算每种疾病的准确性。
结果：VET-SAA比LZ-SAA对初级保健兽医医院最常见的疾病具有更高的敏感性，包括慢性肾病,肿瘤，和牙龈炎.我们的结果揭示了与LZ-SAA相比，使用VET-SAA在健康和患病猫中检测低SAA浓度的能力，仅在患病的猫中发现SAA浓度升高。
结论：我们的研究结果表明，改用新的VET-SAA而不是传统的LZ-SAA可能会提高初级保健兽医医院的诊断性能。
