PDF(Pubmed)
Abstract：
Considering the significant impact of total cholesterol (TC) and vascular endothelin-1 (ET-1) on children sepsis outcomes, this research aimed to explore the association between the levels of plasma cholesterol and vascular endothelin-1 and the severity of sepsis and evaluated its clinical implications. In this study, we examined 250 pediatric patients diagnosed with sepsis between February 2019 and April 2021, collecting data on their plasma levels of TC and ET-1. Depending on the observed outcomes, the participants were divided into 2 categories: a group with a positive prognosis (control group, n = 100) and a group with a negative prognosis (n = 50). We assessed the significance of plasma TC and ET-1 levels in forecasting the outcomes for these pediatric patients. Patients in the group with a poor prognosis experienced notably longer hospital stays and higher treatment expenses than those in the control group (P < .05). Within the first 24 hours of admission and again on days 3 and 7, the levels of ET-1 were significantly higher in the poor prognosis group, whereas plasma TC levels were notably lower in comparison to the control group (P < .05). A Spearman correlation analysis identified a significant correlation between the levels of plasma TC and ET-1 and the severity of sepsis among the children (P < .05). The diagnostic performance for the severity of sepsis in children, as measured by the area under the curve (AUC), was 0.805 for plasma TC, 0.777 for ET-1 levels, and 0.938 when both were combined. This investigation underscores a meaningful relationship between the levels of plasma TC and ET-1 in pediatric sepsis patients, suggesting these biomarkers are highly valuable in predicting patient outcomes. High levels of ET-1 and low levels of TC in these patients signify a grave condition and a poor prognosis.
摘要：
考虑到总胆固醇（TC）和血管内皮素-1（ET-1）对儿童脓毒症结局的显著影响，本研究旨在探讨血浆胆固醇和血管内皮素-1水平与脓毒症严重程度之间的关系，并评估其临床意义。在这项研究中,我们检查了2019年2月至2021年4月间诊断为脓毒症的250例儿科患者,收集了他们血浆TC和ET-1水平的数据.根据观察到的结果，参与者分为2类：预后阳性的组（对照组，n=100）和预后阴性的组（n=50）。我们评估了血浆TC和ET-1水平在预测这些儿科患者预后中的意义。预后不良组患者的住院时间明显长于对照组，治疗费用明显高于对照组（P<0.05）。在入院的最初24小时内以及第3天和第7天，预后不良组的ET-1水平显着升高，而血浆TC水平明显低于对照组（P<0.05）。Spearman相关分析确定血浆TC和ET-1水平与儿童败血症严重程度之间存在显着相关性（P<0.05）。儿童败血症严重程度的诊断表现，通过曲线下面积（AUC）测量，血浆TC为0.805，ET-1水平为0.777，和0.938，当两者结合。这项研究强调了小儿脓毒症患者血浆TC和ET-1水平之间有意义的关系，表明这些生物标志物在预测患者预后方面非常有价值。这些患者中高水平的ET-1和低水平的TC表示严重的病情和不良的预后。
