PDF(Pubmed)
Abstract：
The objective of this study is to investigate the associated risk factors and their effects on cognitive impairment (CI) in patients undergoing peritoneal dialysis. A retrospective analysis was conducted on the basic information of 268 patients who underwent continuous ambulatory peritoneal dialysis (CAPD) at our hospital from January 2020 to September 2023. Cognitive function was assessed using the Montreal Cognitive Assessment Scale during their subsequent dialysis visits. Participants were categorized into a CI group and a cognitively normal group. Blood and other biological samples were collected for relevant biomarker analysis. Subsequently, we analyzed and compared the factors influencing CI between the 2 groups. The prevalence of CI among CAPD patients was 58.2%. Compared to the cognitively normal group, the CI group had a higher prevalence of alcohol consumption, lower levels of education, and reduced serum uric acid levels (P < .05). There was also a higher incidence of autoimmune diseases such as systemic lupus erythematosus in the CI group (P < .05). In terms of dialysis efficacy, the residual kidney Kt/V and residual kidney Ccr were significantly lower in the CI group compared to the cognitively normal group. In blood parameters, the CI group showed elevated total cholesterol levels and lower serum calcium concentrations (P < .05). Logistic regression analysis identified male gender, older age, lower educational attainment, hypercholesterolemia, and elevated high-sensitivity C-reactive protein levels as independent risk factors for CI in CAPD patients (P < .05). Additionally, in this patient cohort, dialysis duration and residual renal function were protective factors against CI (P < .05). CI is prevalent among PD patients. Elevated high-sensitivity C-reactive protein levels, male gender, older age, lower educational attainment, and hypercholesterolemia constitute an independent risk factor for CI in CAPD patients, whereas residual renal function acts as a protective element.
摘要：
这项研究的目的是探讨腹膜透析患者的相关危险因素及其对认知障碍（CI）的影响。回顾性分析2020年1月至2023年9月在我院行持续性非卧床腹膜透析(CAPD)的268例患者的基本资料。在随后的透析访视期间使用蒙特利尔认知评估量表评估认知功能。参与者分为aCI组和认知正常组。收集血液和其他生物样品用于相关生物标志物分析。随后，对影响CI的因素进行分析比较。CAPD患者的CI患病率为58.2%。与认知正常组相比，CI组的饮酒患病率较高，教育水平较低，降低血清尿酸水平(P<0.05)。CI组自身免疫性疾病如系统性红斑狼疮的发生率也较高(P<0.05)。就透析疗效而言，与认知正常组相比，CI组的残余肾Kt/V和残余肾Ccr明显降低。在血液参数中，CI组总胆固醇水平升高，血清钙浓度降低（P<0.05）。Logistic回归分析确定男性性别，年龄较大,受教育程度较低，高胆固醇血症,高敏C反应蛋白水平升高是CAPD患者发生CI的独立危险因素（P<0.05）。此外,在这个病人队列中，透析时间和残余肾功能是CI的保护因素（P<0.05）。CI在PD患者中普遍存在。高敏C反应蛋白水平升高,男性,年龄较大,受教育程度较低，高胆固醇血症构成CAPD患者CI的独立危险因素，而残余的肾功能作为保护元素。
