PDF(Pubmed)
Abstract：
OBJECTIVE: To develop a model that describes how the pancreas functions, how the rate of synthesis of digestive enzymes is regulated, and finally what puts the pancreas to rest between meals.
METHODS: We applied the principals of control theory to previously published canine data to develop a model for how the canine pancreas functions. Using this model, we then describe the steps needed to apply this model to the human pancreas.
RESULTS: This new closed-loop negative feedback model describes what regulates digestive enzyme synthesis. This model is based on basolateral exocytosis of butyrylcholinesterase (BCHE) into the interstitial space. It is this level of BCHE * BCHE activity that controls the rate of canine pancreas digestive enzyme synthesis, and in the absence of stimulation from the vagus nerve, puts the pancreas to rest between meals.
CONCLUSIONS: Finding secretagogue-specific inhibitory enzymes in the human pancreas that are analogous to BCHE in the canine, and blocking its associated receptors, may lead to a cure for human pancreatitis.
METHODS: We applied the principals of control theory to previously published canine data to develop a model for how the canine pancreas functions. Using this model, we then describe the steps needed to apply this model to the human pancreas.
RESULTS: This new closed-loop negative feedback model describes what regulates digestive enzyme synthesis. This model is based on basolateral exocytosis of butyrylcholinesterase (BCHE) into the interstitial space. It is this level of BCHE * BCHE activity that controls the rate of canine pancreas digestive enzyme synthesis, and in the absence of stimulation from the vagus nerve, puts the pancreas to rest between meals.
CONCLUSIONS: Finding secretagogue-specific inhibitory enzymes in the human pancreas that are analogous to BCHE in the canine, and blocking its associated receptors, may lead to a cure for human pancreatitis.
摘要：
目的：建立一个描述胰腺功能的模型，消化酶的合成速率是如何调节的，最后是什么让胰腺在两餐之间休息。
方法：我们将控制理论的原理应用于先前发表的犬科动物数据，以建立犬科动物胰腺功能的模型。使用这个模型，然后，我们描述了将该模型应用于人类胰腺所需的步骤。
结果：这种新的闭环负反馈模型描述了什么调节消化酶合成。该模型基于丁酰胆碱酯酶（BCHE）向间质空间的基底外侧胞吐作用。正是这种BCHE*BCHE活性水平控制了犬胰腺消化酶合成的速率，在没有迷走神经刺激的情况下，让胰腺在两餐之间休息。
结论：在人类胰腺中发现类似于犬BCHE的促分泌素特异性抑制酶，并阻断其相关受体，可能会导致人类胰腺炎的治愈。
方法：我们将控制理论的原理应用于先前发表的犬科动物数据，以建立犬科动物胰腺功能的模型。使用这个模型，然后，我们描述了将该模型应用于人类胰腺所需的步骤。
结果：这种新的闭环负反馈模型描述了什么调节消化酶合成。该模型基于丁酰胆碱酯酶（BCHE）向间质空间的基底外侧胞吐作用。正是这种BCHE*BCHE活性水平控制了犬胰腺消化酶合成的速率，在没有迷走神经刺激的情况下，让胰腺在两餐之间休息。
结论：在人类胰腺中发现类似于犬BCHE的促分泌素特异性抑制酶，并阻断其相关受体，可能会导致人类胰腺炎的治愈。
