Abstract：
UNASSIGNED: Studies that assess cognition prospectively and study in detail anxiety history in the participants\' medical records within the context of brain aging and Alzheimer\'s disease are limited.
UNASSIGNED: To examine the associations of anxiety and unspecified emotional distress (UED) acquired throughout a person\'s life with prospectively collected cognitive outcomes.
UNASSIGNED: Mayo Clinic Study of Aging participants who were cognitively unimpaired at baseline were included. Anxiety and UED data were abstracted from the medical record using the Rochester Epidemiology Project (REP) resources and were run separately as predictors in our models. The data were analyzed using Cox proportional hazards models for the outcomes of incident mild cognitive impairment (MCI) and dementia and using linear mixed effects models for the outcomes of global and domain specific cognitive z-scores and included key covariates.
UNASSIGNED: The study sample (n = 1,808) had a mean (standard deviation) age of 74.5 (7.3) years and 51.4% were male. Anxiety was associated with increased risk of MCI and dementia and was associated with lower baseline cognitive z-scores and accelerated decline over time in the global, memory, and attention domains. UED was associated with faster decline in all domains except visuospatial but did not show evidence of association with incident cognitive outcomes. These results varied by medication use and timing of anxiety.
UNASSIGNED: Anxiety and UED both showed inverse associations with cognition. Utilization of anxiety and UED data from across the life course, as available, from the REP system adds robustness to our results.
UNASSIGNED: To examine the associations of anxiety and unspecified emotional distress (UED) acquired throughout a person\'s life with prospectively collected cognitive outcomes.
UNASSIGNED: Mayo Clinic Study of Aging participants who were cognitively unimpaired at baseline were included. Anxiety and UED data were abstracted from the medical record using the Rochester Epidemiology Project (REP) resources and were run separately as predictors in our models. The data were analyzed using Cox proportional hazards models for the outcomes of incident mild cognitive impairment (MCI) and dementia and using linear mixed effects models for the outcomes of global and domain specific cognitive z-scores and included key covariates.
UNASSIGNED: The study sample (n = 1,808) had a mean (standard deviation) age of 74.5 (7.3) years and 51.4% were male. Anxiety was associated with increased risk of MCI and dementia and was associated with lower baseline cognitive z-scores and accelerated decline over time in the global, memory, and attention domains. UED was associated with faster decline in all domains except visuospatial but did not show evidence of association with incident cognitive outcomes. These results varied by medication use and timing of anxiety.
UNASSIGNED: Anxiety and UED both showed inverse associations with cognition. Utilization of anxiety and UED data from across the life course, as available, from the REP system adds robustness to our results.
摘要：
■在大脑老化和阿尔茨海默病背景下，前瞻性评估认知和详细研究参与者焦虑史的研究是有限的。
■检查一个人一生中获得的焦虑和未指定的情绪困扰（UED）与前瞻性收集的认知结果的关联。
梅奥诊所对基线时认知未受损的衰老参与者的研究被纳入。使用罗切斯特流行病学项目（REP）资源从病历中提取焦虑和UED数据，并在我们的模型中作为预测因子单独运行。使用Cox比例风险模型对轻度认知障碍（MCI）和痴呆的结果进行分析，并使用线性混合效应模型对全局和领域特定认知z评分的结果进行分析，并包括关键协变量。
■研究样本（n=1,808）的平均（标准偏差）年龄为74.5（7.3）岁，男性占51.4％。焦虑与MCI和痴呆的风险增加相关，并与较低的基线认知z评分和随着时间的推移加速下降相关。记忆,和关注领域。UED与除视觉空间外的所有领域的更快下降相关，但没有显示与事件认知结果相关的证据。这些结果因药物使用和焦虑的时机而异。
■焦虑和UED均与认知呈负相关。利用整个生命过程中的焦虑和UED数据，如可用，来自REP系统的结果增加了我们的结果的鲁棒性。
■检查一个人一生中获得的焦虑和未指定的情绪困扰（UED）与前瞻性收集的认知结果的关联。
梅奥诊所对基线时认知未受损的衰老参与者的研究被纳入。使用罗切斯特流行病学项目（REP）资源从病历中提取焦虑和UED数据，并在我们的模型中作为预测因子单独运行。使用Cox比例风险模型对轻度认知障碍（MCI）和痴呆的结果进行分析，并使用线性混合效应模型对全局和领域特定认知z评分的结果进行分析，并包括关键协变量。
■研究样本（n=1,808）的平均（标准偏差）年龄为74.5（7.3）岁，男性占51.4％。焦虑与MCI和痴呆的风险增加相关，并与较低的基线认知z评分和随着时间的推移加速下降相关。记忆,和关注领域。UED与除视觉空间外的所有领域的更快下降相关，但没有显示与事件认知结果相关的证据。这些结果因药物使用和焦虑的时机而异。
■焦虑和UED均与认知呈负相关。利用整个生命过程中的焦虑和UED数据，如可用，来自REP系统的结果增加了我们的结果的鲁棒性。
