Abstract：
Chronic kidney disease (CKD) is a major cause of morbidity and mortality worldwide, but few studies are available on CKD in Cote d\'Ivoire. We aimed to assess the prevalence of CKD and identify its associated factors in the general population in Abidjan in 2016 in a cross-sectional study that included 1418 subjects. We did not receive laboratory data for 38 subjects, including serum creatinine data. Of the 1380 remaining subjects, 138 cases of CKD were included in the study (10% prevalence). We observed a female predominance (sex ratio = 0.81), and the mean age was 43.7 ± 14.5 years. Histories of hypertension (HTN) (29.7%) and diabetes (10.1%) were reported. The main clinical signs were high blood pressure (51.4%), obesity (21%), proteinuria (37.9%), and hematuria (37.4%). The glomerular filtration rate (GFR) was <60 mL/min in 8.2% of cases according to the Modification of Diet in Renal Disease equation, in 8.6% according to the CKD Epidemiology Collaboration equation, and in 12.6% according to the Cockroft-Gault (CG) equation. The other laboratory signs were hyperglycemia (51.4%), hypercholesterolemia (34.1%), and hyperlipidemia (21%). In the multivariate analysis, factors such as female sex (P = 0.013), age >55 years (P = 0.02), a history of HTN (P = 0.001), hypercholesterolemia (P = 0.010), and hyperlipidemia (P = 0.009) were associated with the risk of CKD. The prevalence of CKD was high in our study. The CG equation should not be used to estimate the GFR in the general population. Prevention involves managing modifiable risk factors.
摘要：
慢性肾脏病（CKD）是全球范围内发病率和死亡率的主要原因。但在科特迪瓦，关于CKD的研究很少。我们旨在评估CKD的患病率，并在2016年阿比让普通人群中确定其相关因素，该研究包括1418名受试者。我们没有收到38名受试者的实验室数据，包括血清肌酐数据。在剩下的1380个科目中，138例CKD患者纳入研究（10%患病率）。我们观察到女性占主导地位（性别比=0.81），平均年龄为43.7±14.5岁。报告了高血压（HTN）（29.7％）和糖尿病（10.1％）的历史。主要临床体征为高血压(51.4%),肥胖（21%），蛋白尿（37.9%），血尿(37.4%)。根据肾脏病饮食方程的修正，8.2%的病例肾小球滤过率(GFR)<60mL/min，根据CKD流行病学合作方程，8.6%，根据Cockroft-Gault(CG)方程，为12.6%。其他实验室体征为高血糖（51.4%），高胆固醇血症（34.1%），和高脂血症（21%）。在多变量分析中，女性等因素(P=0.013)，年龄>55岁（P=0.02），HTN病史（P=0.001），高胆固醇血症（P=0.010），和高脂血症(P=0.009)与CKD风险相关。我们的研究中CKD的患病率很高。CG方程不应用于估计一般人群的GFR。预防涉及管理可修改的风险因素。
