Abstract：
Recently, the effect of an aqueous extract of asafetida on acute angiotensin II hypertensive rats was evaluated. The present study evaluated the antihypertensive and antioxidant effects of asafetida on a rat model of renovascular hypertension (RVH) using four groups. RVH was induced by clipping the renal artery; the sham group underwent surgery but without clipping. The RVH rats received losartan (Los, an AT1 receptor antagonist) or asafetida by gavage for 4 weeks. On the 28th day, the femoral artery was cannulated, and the systolic blood pressure (SBP), mean arterial pressure (MAP), and heart rate (HR) were recorded. Finally, the levels of superoxide dismutase (SOD) activity, malondialdehyde (MDA), and total thiol content in the kidney and heart tissues were measured. In RVH rats, SBP and MAP significantly increased compared with the control. Los and the extract significantly reduced the changes in SBP, MAP, and HR that were induced in the RVH rats (P <0.05-0.001). In RVH rats, levels of MDA significantly increased and the content of total thiol and SOD decreased in both the heart and kidney tissues. Los plus the extract significantly decreased MDA and increased total thiol and SOD in the heart and kidney tissues. We concluded that an aqueous extract of asafetida gum has antihypertensive and antioxidant effects in the RVH rat model. The effect of the extract is similar to that of Los, which suggests that this effect of asafetida is mediated via an effect on the angiotensin Type I receptor.
摘要：
最近,评价了asafetida水提取物对急性血管紧张素II高血压大鼠的作用。本研究使用四组评估了asafetida对肾血管性高血压（RVH）大鼠模型的降压和抗氧化作用。通过夹闭肾动脉诱导RVH；假手术组接受了手术，但没有夹闭。RVH大鼠接受氯沙坦(Los，AT1受体拮抗剂）或asafetida通过管饲4周。第28天,股动脉插管,收缩压（SBP），平均动脉压(MAP),记录心率（HR）。最后,超氧化物歧化酶（SOD）活性的水平，丙二醛（MDA），并测定了肾脏和心脏组织中的总硫醇含量。在RVH大鼠中，与对照相比,SBP和MAP显著增加。Los和提取物显着降低了SBP的变化，MAP,和在RVH大鼠中诱导的HR（P<0.05-0.001）。在RVH大鼠中，心脏和肾脏组织中MDA的含量显着增加，总硫醇和SOD的含量降低。Losplus提取物显着降低了心脏和肾脏组织中的MDA，增加了总硫醇和SOD。我们得出的结论是，在RVH大鼠模型中，asafetida胶的水提取物具有降压和抗氧化作用。提取物的效果与Los相似，这表明asafetida的这种作用是通过对血管紧张素I型受体的作用介导的。
