PDF(Pubmed)
Abstract：
This study investigated the growth performance, nutrient utilization, and intestinal health responses of Eimeria-challenged broiler chickens to dietary Spirulina (Arthrospira platensis). On day 1, birds were assigned to 2 diets supplemented with Spirulina (0 or 5 g/kg) in a randomized complete block design. The birds within each diet were divided into 2 Eimeria-challenge groups (challenge or no-challenge) and that resulted in a 2 × 2 factorial arrangement with 2 levels each of Spirulina and challenge on day 14. On day 15, the birds in the challenge or no-challenge groups were orally gavaged with a solution containing Eimeria oocysts or 1% PBS, respectively. Samples were collected on days 21 and 26 (6- and 11-d post-infection; dpi). Data collected from days 1 to 26 were analyzed using the MIXED procedure of SAS. Birds that were fed Spirulina-supplemented diets had increased (P < 0.05) BW gain, gain-to-feed ratio, and total tract retention nitrogen from days 14 to 21. The ileal villus perimeter and area, serum catalase, HMOX1 and SOD1 jejunal abundance were all increased (P < 0.05) in birds fed Spirulina-supplemented diets on day 21 (6 dpi). However, there was no effect on bone ash or oocyst count. From days 21 to 26, there was a tendency (P = 0.059) for a Spirulina × Challenge interaction on the BW gain of birds. Moreover, dietary Spirulina addition increased (P < 0.05) serum catalase, total antioxidant capacity, ileal villus perimeter, tibia bone ash, and the relative mRNA expression of HMOX1, SOD1, claudin 1, and TNFα in the jejunal mucosa of birds on day 26 (11 dpi). On both 6 and 11 dpi, the Eimeria challenge negatively (P < 0.05) impacted growth performance, gut morphology, and the relative mRNA expression of genes. Overall, assessing the impact of Spirulina in broilers revealed its positive antioxidant, immune-modulating, and health benefits. However, its dietary addition did not completely reverse the Eimeria-induced effects in these birds. Ultimately, this study outlines the positive properties of dietary Spirulina beyond its use in the diet of healthy broiler chickens.
In recent years, nutritional strategies for managing coccidiosis in broiler chickens have focused on feed additives, amino acids, and minerals. Spirulina, a cyanobacterium, is a feed additive rich in bioactive compounds like phycocyanin, polysaccharides, B vitamins, minerals, polyunsaturated fatty acids, and carotenoids. These compounds confer antioxidant, anti-inflammatory, and immunomodulatory properties to Spirulina. While Spirulina has been extensively explored as a health supplement in humans, its dietary application in broiler chickens and pigs is now gaining attention. Additionally, its potential to combat the Eimeria-induced effects on growth performance, nutrient digestibility, and health in birds has not been adequately addressed. Hence, the aim of this study was to investigate the effect of Spirulina on growth performance, nutrient digestibility, immune response, bone mineral deposition, and serum phosphorus in Eimeria-challenged broiler chickens. Results from this study showed that the positive properties of dietary Spirulina extend beyond its use in the diet of healthy broiler chickens as it reduced some of the negative impact of an Eimeria infection in birds.
In recent years, nutritional strategies for managing coccidiosis in broiler chickens have focused on feed additives, amino acids, and minerals. Spirulina, a cyanobacterium, is a feed additive rich in bioactive compounds like phycocyanin, polysaccharides, B vitamins, minerals, polyunsaturated fatty acids, and carotenoids. These compounds confer antioxidant, anti-inflammatory, and immunomodulatory properties to Spirulina. While Spirulina has been extensively explored as a health supplement in humans, its dietary application in broiler chickens and pigs is now gaining attention. Additionally, its potential to combat the Eimeria-induced effects on growth performance, nutrient digestibility, and health in birds has not been adequately addressed. Hence, the aim of this study was to investigate the effect of Spirulina on growth performance, nutrient digestibility, immune response, bone mineral deposition, and serum phosphorus in Eimeria-challenged broiler chickens. Results from this study showed that the positive properties of dietary Spirulina extend beyond its use in the diet of healthy broiler chickens as it reduced some of the negative impact of an Eimeria infection in birds.
摘要：
这项研究调查了增长表现，养分利用率，和艾美球虫攻击的肉鸡对饮食螺旋藻（Arthrospiraplatensis）的肠道健康反应。在第1天，以随机完整的区组设计将鸟类分配给2种补充螺旋藻（0或5g/kg）的饮食。将每种饮食中的鸟类分为2个艾美球虫挑战组（挑战或不挑战），这导致2×2阶乘排列，每个螺旋藻有2个等级，在第14天挑战。在第15天，用含有艾美耳球虫卵囊或1％PBS的溶液口服灌胃攻击或未攻击组中的鸟类，分别。在第21天和第26天(感染后6天和11天;dpi)收集样品。从d1到26收集的数据使用SAS的MIXED程序进行分析。饲喂螺旋藻补充饮食的鸟类增加了（P<0.05）BW，增益与进料比，和第14天至第21天的总保留氮。回肠绒毛的周长和面积，血清过氧化氢酶,在第21天（6dpi）饲喂补充螺旋藻的日粮中，HMOX1和SOD1空肠丰度均增加（P<0.05）。然而,对骨灰或卵囊计数无影响。从第21天到第26天，螺旋藻×挑战相互作用对鸟类的体重增加有趋势（P=0.059）。此外，饲粮添加SP增加血清过氧化氢酶(P<0.05),总抗氧化能力，回肠绒毛周边，胫骨骨灰,d26（11dpi）时，鸟类空肠粘膜中HMOX1，SOD1，claudin1和TNFα的相对mRNA表达。在6和11dpi上，艾美球虫挑战对生长性能产生负面影响(P<0.05)，肠道形态学,和基因的相对mRNA表达。总的来说,评估螺旋藻对肉鸡的影响揭示了其积极的抗氧化剂，免疫调节，和健康益处。然而,它的饮食添加并不能完全逆转艾美球虫在这些鸟类中引起的影响。最终,这项研究概述了螺旋藻在健康肉鸡饮食中的积极特性。
