Abstract：
Newborns and young infants are at risk for severe respiratory syncytial virus (RSV) lower respiratory tract infection. Passive immunity is the mainstay of infection prevention in this cohort. Transplacental transfer of maternal antibodies provides the newborn with immediate protection from life-threatening infections, however, is dependent upon gestational age, birth weight, mother\'s age, recent maternal vaccination, maternal nutritional status, maternal immunocompetence and medical conditions, and placental integrity. Efficient transplacental transfer of RSV-neutralizing antibodies have led to the development and approval of maternal RSV immunization for the protection of the newborn. Additionally, administration of RSV-specific antibodies to infants leads to high serum titers of RSV-neutralizing antibodies and further protection from severe disease.
摘要：
新生儿和幼儿面临严重呼吸道合胞病毒（RSV）下呼吸道感染的风险。被动免疫是该队列中预防感染的主要手段。母体抗体的胎盘转移为新生儿提供了立即保护，免受危及生命的感染，然而,取决于胎龄，出生体重,母亲的年龄，最近孕妇接种疫苗，产妇营养状况,母体免疫能力和医疗条件，和胎盘完整性。RSV中和抗体的有效经胎盘转移已导致开发和批准用于保护新生儿的母体RSV免疫。此外,给婴儿施用RSV特异性抗体导致RSV中和抗体的高血清滴度,并进一步保护免受严重疾病的影响。
