PDF(Pubmed)
Abstract：
Dentin pulp has a complex function as a major unit in maintaining the vitality of teeth. In this sense, the Wnt/β-Catenin pathway has a vital part in tooth development, maintenance, repair, and regeneration by controlling physiological activities such as growth, differentiation, and migration. This pathway consists of a network of proteins, such as Wnt signaling molecules, which interact with receptors of targeted cells and play a role in development and adult tissue homeostasis. The Wnt signals are specific spatiotemporally, suggesting its intricate mechanism in development, regulation, repair, and regeneration by the formation of tertiary dentin. This review provides an overview of the recent advances in the Wnt/β-Catenin signaling pathway in dentin and pulp regeneration, how different proteins, molecules, and ligands influence this pathway, either upregulating or silencing it, and how it may be used in the future for clinical dentistry, in vital pulp therapy as an effective treatment for dental caries, as an alternative approach for root canal therapy, and to provide a path for therapeutic and regenerative dentistry.
摘要：
牙本质牙髓作为维持牙齿活力的主要单元具有复杂的功能。在这个意义上,Wnt/β-Catenin通路在牙齿发育中具有重要作用,维护,修复,通过控制生长等生理活动来再生，分化,和移民。这个通路由蛋白质组成的网络，如Wnt信号分子，它们与靶细胞的受体相互作用，并在发育和成人组织稳态中起作用。Wnt信号在时空上是特定的，暗示了其复杂的发展机制，regulation,修复,并通过三级牙本质的形成而再生。本文综述了Wnt/β-Catenin信号通路在牙本质和牙髓再生中的研究进展。不同的蛋白质，分子，配体影响这个途径，要么上调它，要么沉默它，以及它将来如何用于临床牙科，在重要的牙髓疗法中，作为龋齿的有效治疗方法，作为根管治疗的替代方法，并为治疗和再生牙科提供路径。
