PDF(Pubmed)
Abstract：
Skin provides a physical and immune barrier to protect the body from foreign substances, microbial invasion, and desiccation. Aging reduces the barrier function of skin and its rate of repair. Aged skin exhibits decreased mitochondrial function and prolonged low-level inflammation that can be seen in other organs with aging. Peroxisome proliferator-activated receptor (PPAR)-γ coactivator-1α (PGC-1α), an important transcriptional coactivator, plays a central role in modulating mitochondrial function and antioxidant production. Mitochondrial function and inflammation have been linked to epidermal function, but the mechanisms are unclear. The aim of this review is to discuss the mechanisms by which PGC-1α might exert a positive effect on aged skin barrier function. Initially, we provide an overview of the function of skin under physiological and aging conditions, focusing on the epidermis. We then discuss mitochondrial function, oxidative stress, cellular senescence, and inflamm-aging, the chronic low-level inflammation observed in aging individuals. Finally, we discuss the effects of PGC-1α on mitochondrial function, as well as the regulation and role of PGC-1α in the aging epidermis.
摘要：
皮肤提供物理和免疫屏障，以保护身体免受外来物质的侵害，微生物入侵,和干燥。老化会降低皮肤的屏障功能及其修复率。衰老的皮肤表现出线粒体功能下降和低水平炎症的延长，这在其他器官随着衰老而可见。过氧化物酶体增殖物激活受体(PPAR)-γ共激活因子-1α(PGC-1α),一个重要的转录共激活因子，在调节线粒体功能和抗氧化剂产生中起着核心作用。线粒体功能和炎症与表皮功能有关，但机制尚不清楚。这篇综述的目的是讨论PGC-1α可能对衰老皮肤屏障功能产生积极影响的机制。最初，我们概述了皮肤在生理和衰老条件下的功能，专注于表皮。然后我们讨论线粒体功能，氧化应激，细胞衰老,和炎症老化，在衰老个体中观察到的慢性低水平炎症。最后,我们讨论了PGC-1α对线粒体功能的影响，以及PGC-1α在衰老表皮中的调控和作用。
