PDF(Pubmed)
Abstract：
The Notch communication pathway, discovered in Drosophila over 100 years ago, regulates a wide range of intra-lineage decisions in metazoans. The division of the Drosophila mechanosensory organ precursor is the archetype of asymmetric cell division in which differential Notch activation takes place at cytokinesis. Here, we review the molecular mechanisms by which epithelial cell polarity, cell cycle and intracellular trafficking participate in controlling the directionality, subcellular localization and temporality of mechanosensitive Notch receptor activation in cytokinesis.
摘要：
Notch通讯通路,100多年前在果蝇中发现的，在后生动物中调节了广泛的谱系内决策。果蝇机械感觉器官前体的分裂是不对称细胞分裂的原型，其中差异Notch激活在胞质分裂时发生。这里,我们回顾了上皮细胞极性的分子机制，细胞周期和胞内运输参与控制方向性，胞质分裂中机械敏感性Notch受体激活的亚细胞定位和时间性。
