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Abstract：
UNASSIGNED: To analyze marital outcomes, divorce or separation, and its association with demographic, socioeconomic, and clinicopathological factors among breast cancer (BC) survivors after 2-years of diagnosis.
UNASSIGNED: We performed a retrospective analysis of marital status at baseline and at years 1 and 2 of follow-up of women aged ≥ 18 years diagnosed with invasive BC participating in the AMAZONA III (GBECAM0115) study. The BC diagnosis occurred between January 2016 and March 2018 at 23 institutions in Brazil.
UNASSIGNED: Of the 2974 women enrolled in AMAZONA III, 599 were married or living under common law at baseline. Divorce or separation occurred in 35 (5.8%) patients at 2 years of follow-up. In the multivariate analysis, public health insurance coverage was associated with a higher risk of marital status change (8.25% vs. 2.79%, RR 3.09, 95% CI 1.39 - 7.03, p = 0.007). Women who underwent mastectomy, adenomastectomy or skin-sparing mastectomy were associated with a higher risk of divorce or separation (8.1% vs. 4.49%, RR 1.97, 95 CI 1.04 - 3.72, p = 0.0366) than those who underwent breast-conserving surgery.
UNASSIGNED: Women covered by the public health system and those who underwent mastectomy, adenomastectomy or skin-sparing mastectomy were associated with a higher risk of divorce or separation. This evidence further supports the idea that long-term marital stability is associated with a complex interplay between socioeconomic conditions and stressors, such as BC diagnosis and treatment. ClinicalTrials Registration: NCT02663973.
UNASSIGNED: We performed a retrospective analysis of marital status at baseline and at years 1 and 2 of follow-up of women aged ≥ 18 years diagnosed with invasive BC participating in the AMAZONA III (GBECAM0115) study. The BC diagnosis occurred between January 2016 and March 2018 at 23 institutions in Brazil.
UNASSIGNED: Of the 2974 women enrolled in AMAZONA III, 599 were married or living under common law at baseline. Divorce or separation occurred in 35 (5.8%) patients at 2 years of follow-up. In the multivariate analysis, public health insurance coverage was associated with a higher risk of marital status change (8.25% vs. 2.79%, RR 3.09, 95% CI 1.39 - 7.03, p = 0.007). Women who underwent mastectomy, adenomastectomy or skin-sparing mastectomy were associated with a higher risk of divorce or separation (8.1% vs. 4.49%, RR 1.97, 95 CI 1.04 - 3.72, p = 0.0366) than those who underwent breast-conserving surgery.
UNASSIGNED: Women covered by the public health system and those who underwent mastectomy, adenomastectomy or skin-sparing mastectomy were associated with a higher risk of divorce or separation. This evidence further supports the idea that long-term marital stability is associated with a complex interplay between socioeconomic conditions and stressors, such as BC diagnosis and treatment. ClinicalTrials Registration: NCT02663973.
摘要：
■要分析婚姻结局，离婚或分居,以及它与人口统计的联系，社会经济,诊断2年后乳腺癌（BC）幸存者的临床病理因素。
■我们对参与AMAZONAIII（GBECAM0115）研究的年龄≥18岁诊断为侵袭性BC的女性进行了基线和随访第1年和第2年的婚姻状况回顾性分析。BC诊断发生在2016年1月至2018年3月之间，在巴西的23个机构中。
■在参加AMAZONAIII的2974名女性中，599人在基线时已婚或生活在普通法下。在随访2年时，35例（5.8％）患者发生了离婚或分居。在多变量分析中，公共健康保险覆盖率与较高的婚姻状况变化风险相关(8.25%与2.79%,RR3.09，95%CI1.39-7.03，p=0.007）。做了乳房切除术的女性,腺样体切除术或保留皮肤的乳房切除术与离婚或分居的风险较高(8.1%vs.4.49%,RR1.97，95CI1.04-3.72，p=0.0366）比接受保乳手术的患者高。
■公共卫生系统覆盖的妇女和接受乳房切除术的妇女，乳腺腺切除术或保留皮肤的乳房切除术与较高的离婚或分居风险相关。这一证据进一步支持了长期婚姻稳定与社会经济条件和压力源之间复杂的相互作用有关的观点。如BC的诊断和治疗。临床试验注册：NCT02663973。
■我们对参与AMAZONAIII（GBECAM0115）研究的年龄≥18岁诊断为侵袭性BC的女性进行了基线和随访第1年和第2年的婚姻状况回顾性分析。BC诊断发生在2016年1月至2018年3月之间，在巴西的23个机构中。
■在参加AMAZONAIII的2974名女性中，599人在基线时已婚或生活在普通法下。在随访2年时，35例（5.8％）患者发生了离婚或分居。在多变量分析中，公共健康保险覆盖率与较高的婚姻状况变化风险相关(8.25%与2.79%,RR3.09，95%CI1.39-7.03，p=0.007）。做了乳房切除术的女性,腺样体切除术或保留皮肤的乳房切除术与离婚或分居的风险较高(8.1%vs.4.49%,RR1.97，95CI1.04-3.72，p=0.0366）比接受保乳手术的患者高。
■公共卫生系统覆盖的妇女和接受乳房切除术的妇女，乳腺腺切除术或保留皮肤的乳房切除术与较高的离婚或分居风险相关。这一证据进一步支持了长期婚姻稳定与社会经济条件和压力源之间复杂的相互作用有关的观点。如BC的诊断和治疗。临床试验注册：NCT02663973。
