PDF(Pubmed)
Abstract：
Ferroptosis, a new type of programmed cell death proposed in recent years, is characterized mainly by reactive oxygen species and iron-mediated lipid peroxidation and differs from programmed cell death, such as apoptosis, necrosis, and autophagy. Ferroptosis is associated with a variety of physiological and pathophysiological processes. Recent studies have shown that ferroptosis can aggravate or reduce the occurrence and development of diseases by targeting metabolic pathways and signaling pathways in tumors, ischemic organ damage, and other degenerative diseases related to lipid peroxidation. Increasing evidence suggests that ferroptosis is closely linked to the onset and progression of various ophthalmic conditions, including corneal injury, glaucoma, age-related macular degeneration, diabetic retinopathy, retinal detachment, and retinoblastoma. Our review of the current research on ferroptosis in ophthalmic diseases reveals significant advancements in our understanding of the pathogenesis, aetiology, and treatment of these conditions.
摘要：
Ferroptosis,近年来提出的一种新型的程序性细胞死亡，主要以活性氧和铁介导的脂质过氧化为特征，不同于程序性细胞死亡，如细胞凋亡，坏死,和自噬。铁凋亡与多种生理和病理生理过程有关。最近的研究表明，铁凋亡可以通过靶向肿瘤中的代谢通路和信号通路来加重或减少疾病的发生和发展。缺血性器官损伤，和其他与脂质过氧化有关的退行性疾病。越来越多的证据表明，铁性凋亡与各种眼科疾病的发生和进展密切相关，包括角膜损伤,青光眼,年龄相关性黄斑变性,糖尿病视网膜病变，视网膜脱离,和视网膜母细胞瘤.我们对眼科疾病中铁死亡的当前研究的回顾揭示了我们对发病机理的理解的重大进展。病因学，以及这些疾病的治疗。
