PDF(Pubmed)
Abstract：
UNASSIGNED: Nontraumatic brain injury encompasses various pathological processes and medical conditions that result in brain dysfunction and neurological impairment without direct physical trauma. The study aimed to assess the efficacy of intravenous administration of 20% mannitol and 3% hypertonic saline to reduce intracranial pressure in nontraumatic brain injury.
UNASSIGNED: The Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines were followed for study selection and data extraction. The search was conducted in the PubMed, Embase, and Scopus databases, including articles published in English from January 2003 to December 2023. Our study included randomized controlled trials, comparative studies, prospective analyses, and retrospective cohort studies. We extracted data on baseline characteristics of patients, intervention details, major outcomes, and complications. Quality assessment was performed using the Jadad scale and the Robvis assessment tool for risk of bias.
UNASSIGNED: A total of 14 studies involving 1,536 patients were included in the analysis. Seven studies reported hypertonic saline as more effective in reducing intracranial pressure, while three studies found similar effectiveness for both interventions. Adverse events were reported in only three studies. The studies that reported complication rates ranged from 21 to 79%. A meta-analysis was conducted on five studies, showing varying rates of adverse events associated with mannitol and hypertonic saline.
UNASSIGNED: Both hypertonic saline solution and mannitol have been explored as treatment options for decreasing intracranial pressure in nontraumatic brain injuries. While some studies indicate the superiority of hypertonic saline, others report similar effectiveness between the two interventions.
UNASSIGNED: Choudhury A, Ravikant, Bairwa M, Jithesh G, Kumar S, Kumar N. Efficacy of Intravenous 20% Mannitol vs 3% Hypertonic Saline in Reducing Intracranial Pressure in Nontraumatic Brain Injury: A Systematic Review and Meta-analysis. Indian J Crit Care Med 2024;28(7):686-695.
UNASSIGNED: The Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines were followed for study selection and data extraction. The search was conducted in the PubMed, Embase, and Scopus databases, including articles published in English from January 2003 to December 2023. Our study included randomized controlled trials, comparative studies, prospective analyses, and retrospective cohort studies. We extracted data on baseline characteristics of patients, intervention details, major outcomes, and complications. Quality assessment was performed using the Jadad scale and the Robvis assessment tool for risk of bias.
UNASSIGNED: A total of 14 studies involving 1,536 patients were included in the analysis. Seven studies reported hypertonic saline as more effective in reducing intracranial pressure, while three studies found similar effectiveness for both interventions. Adverse events were reported in only three studies. The studies that reported complication rates ranged from 21 to 79%. A meta-analysis was conducted on five studies, showing varying rates of adverse events associated with mannitol and hypertonic saline.
UNASSIGNED: Both hypertonic saline solution and mannitol have been explored as treatment options for decreasing intracranial pressure in nontraumatic brain injuries. While some studies indicate the superiority of hypertonic saline, others report similar effectiveness between the two interventions.
UNASSIGNED: Choudhury A, Ravikant, Bairwa M, Jithesh G, Kumar S, Kumar N. Efficacy of Intravenous 20% Mannitol vs 3% Hypertonic Saline in Reducing Intracranial Pressure in Nontraumatic Brain Injury: A Systematic Review and Meta-analysis. Indian J Crit Care Med 2024;28(7):686-695.
摘要：
■非创伤性脑损伤包括各种病理过程和医疗条件，导致脑功能障碍和神经功能缺损，而没有直接的身体创伤。该研究旨在评估20％甘露醇和3％高渗盐水静脉给药在非创伤性脑损伤中降低颅内压的功效。
■遵循系统评价和荟萃分析指南的首选报告项目进行研究选择和数据提取。搜索是在PubMed中进行的，Embase,和Scopus数据库，包括2003年1月至2023年12月以英文发表的文章。我们的研究包括随机对照试验，比较研究,前瞻性分析，和回顾性队列研究。我们提取了患者基线特征的数据，干预细节，主要成果,和并发症。使用Jadad量表和Robvis评估工具对偏倚风险进行质量评估。
■共有14项研究纳入分析，涉及1,536名患者。七项研究报告高渗盐水对降低颅内压更有效，而三项研究发现两种干预措施的有效性相似。只有三项研究报告了不良事件。报告并发症发生率的研究范围为21％至79％。对五项研究进行了荟萃分析，显示与甘露醇和高渗盐水相关的不良事件发生率不同。
■高渗盐溶液和甘露醇均已被用作降低非创伤性脑损伤颅内压的治疗选择。虽然一些研究表明高渗盐水的优越性，其他人报告两种干预措施的有效性相似。
■ChoudhuryA,Ravikant,BairwaM,JitheshG,KumarS,20％甘露醇与3％高渗盐水在非创伤性脑损伤中降低颅内压的疗效：系统评价和荟萃分析。印度J暴击护理中心2024；28（7）：686-695。
■遵循系统评价和荟萃分析指南的首选报告项目进行研究选择和数据提取。搜索是在PubMed中进行的，Embase,和Scopus数据库，包括2003年1月至2023年12月以英文发表的文章。我们的研究包括随机对照试验，比较研究,前瞻性分析，和回顾性队列研究。我们提取了患者基线特征的数据，干预细节，主要成果,和并发症。使用Jadad量表和Robvis评估工具对偏倚风险进行质量评估。
■共有14项研究纳入分析，涉及1,536名患者。七项研究报告高渗盐水对降低颅内压更有效，而三项研究发现两种干预措施的有效性相似。只有三项研究报告了不良事件。报告并发症发生率的研究范围为21％至79％。对五项研究进行了荟萃分析，显示与甘露醇和高渗盐水相关的不良事件发生率不同。
■高渗盐溶液和甘露醇均已被用作降低非创伤性脑损伤颅内压的治疗选择。虽然一些研究表明高渗盐水的优越性，其他人报告两种干预措施的有效性相似。
■ChoudhuryA,Ravikant,BairwaM,JitheshG,KumarS,20％甘露醇与3％高渗盐水在非创伤性脑损伤中降低颅内压的疗效：系统评价和荟萃分析。印度J暴击护理中心2024；28（7）：686-695。
