PDF(Pubmed)
Abstract：
Small intestinal bacterial overgrowth (SIBO) is characterized by an increase in the bacterial population of the small intestine due to an imbalance between the amount of bacteria and the intestinal barrier. Pediatric SIBO presents with a wide spectrum of symptoms, ranging from mild gastrointestinal complaints to malabsorption or malnutrition. Breath tests are commonly used as noninvasive diagnostic tools for SIBO, but a standardized methodology is currently unavailable. Intestinal flora produces methane which slows intestinal transit and increases the contractile activity of small intestine. Emerging literature suggests a correlation between overgrowth of methanogenic bacteria in the intestines and constipation. Treatment of SIBO involves administration of antibacterial therapy in addition to management of underlying conditions and optimal dietary adjustments. However, research on antibiotic treatment for pediatric patients with constipation and SIBO is limited and has yielded conflicting results. In the current review, we summarize the state-of-the-art of the field and discuss previous treatment attempts and currently used regimens for SIBO patients with constipation, with a focus on pediatric populations.
摘要：
小肠细菌过度生长(SIBO)的特征在于,由于细菌量和肠屏障之间的不平衡,小肠的细菌种群增加。儿科SIBO表现出广泛的症状，从轻度胃肠道不适到吸收不良或营养不良。呼吸测试通常用作SIBO的非侵入性诊断工具，但是目前没有标准化的方法。肠道菌群产生甲烷，减缓肠道运输并增加小肠的收缩活动。新兴文献表明，肠道中产甲烷细菌的过度生长与便秘之间存在相关性。SIBO的治疗除了管理潜在的病症和最佳的饮食调整之外还涉及抗菌治疗的施用。然而,针对便秘和SIBO患儿的抗生素治疗研究有限,结果相互矛盾.在当前的审查中，我们总结了该领域的最新技术，并讨论了以前的SIBO便秘患者的治疗尝试和目前使用的方案，专注于儿科人群。
