PDF(Pubmed)
Abstract：
UNASSIGNED: Given the importance of medication adherence among individuals with bipolar disorder (BD), this analysis from an ongoing randomized controlled trial (RCT) examined the relationship between BD symptoms, functioning and adherence in 69 poorly adherent adults with BD.
UNASSIGNED: Study inclusion criteria included being ≥ 18 years old with BD Type 1 or 2, difficulties with medication adherence and actively symptomatic as measured by Brief Psychiatric Rating Scale (BPRS) score ≥ 36, Young Mania Rating Scale (YMRS) > 8 or Montgomery Asberg Depression Rating Scale (MADRS) > 8. Adherence was measured in 2 ways: 1) the self-reported Tablets Routine Questionnaire (TRQ) and 2) electronic pill container monitoring (eCap pillbox). BD symptoms and functioning were measured with the MADRS, YMRS, Clinical Global Impressions Scale (CGI), and Global Assessment of Functioning (GAF). Only screening and baseline data were examined.
UNASSIGNED: Mean age was 42.32 (SD = 12.99) years, with 72.46% (n = 50) female and 43.48% (n = 30) non-white. Mean past 7-day percentage of days with missed BD medications using TRQ was 40.63% (SD = 32.61) and 30.30% (SD = 30.41) at screening and baseline, respectively. Baseline adherence using eCap was 42.16% (SD = 35.85) in those with available eCap data (n = 41). Worse adherence based on TRQ was significantly associated with higher MADRS (p = 0.04) and CGI (p = .03) but lower GAF (p = 0.02). eCAP measured adherence was not significantly associated with clinical variables.
UNASSIGNED: While depression and functioning were approximate markers of adherence, reliance on patient self-report or BD symptom presentation may give an incomplete picture of medication-taking behaviors.
UNASSIGNED: Study inclusion criteria included being ≥ 18 years old with BD Type 1 or 2, difficulties with medication adherence and actively symptomatic as measured by Brief Psychiatric Rating Scale (BPRS) score ≥ 36, Young Mania Rating Scale (YMRS) > 8 or Montgomery Asberg Depression Rating Scale (MADRS) > 8. Adherence was measured in 2 ways: 1) the self-reported Tablets Routine Questionnaire (TRQ) and 2) electronic pill container monitoring (eCap pillbox). BD symptoms and functioning were measured with the MADRS, YMRS, Clinical Global Impressions Scale (CGI), and Global Assessment of Functioning (GAF). Only screening and baseline data were examined.
UNASSIGNED: Mean age was 42.32 (SD = 12.99) years, with 72.46% (n = 50) female and 43.48% (n = 30) non-white. Mean past 7-day percentage of days with missed BD medications using TRQ was 40.63% (SD = 32.61) and 30.30% (SD = 30.41) at screening and baseline, respectively. Baseline adherence using eCap was 42.16% (SD = 35.85) in those with available eCap data (n = 41). Worse adherence based on TRQ was significantly associated with higher MADRS (p = 0.04) and CGI (p = .03) but lower GAF (p = 0.02). eCAP measured adherence was not significantly associated with clinical variables.
UNASSIGNED: While depression and functioning were approximate markers of adherence, reliance on patient self-report or BD symptom presentation may give an incomplete picture of medication-taking behaviors.
摘要：
■鉴于药物依从性在双相情感障碍（BD）患者中的重要性，这项来自一项正在进行的随机对照试验(RCT)的分析检查了BD症状之间的关系，69例粘附性差的BD成人的功能和依从性。
■研究纳入标准包括年龄≥18岁，BD1型或2型，药物依从性困难和积极症状，通过简明精神病评定量表（BPRS）评分≥36，年轻躁狂评定量表（YMRS）>8或蒙哥马利·阿斯伯格抑郁评定量表（MADRS）>8。通过2种方式测量依从性：1）自我报告的片剂常规问卷（TRQ）和2）电子药丸容器监测（eCappillbox）。BD症状和功能用MADRS测量，YMRS,临床整体印象量表（CGI），全球功能评估（GAF）。仅检查筛选和基线数据。
■平均年龄42.32(SD=12.99)岁,72.46%(n=50)女性和43.48%(n=30)非白人。在筛查和基线时，使用TRQ错过BD药物治疗的过去7天平均百分比为40.63%(SD=32.61)和30.30%(SD=30.41)。分别。使用eCap的基线依从性为42.16%（SD=35.85），那些有eCap数据的人（n=41）。基于TRQ的较差依从性与较高的MADRS（p=0.04）和CGI（p=0.03）但较低的GAF（p=0.02）显着相关。eCAP测量的依从性与临床变量无显著相关。
■虽然抑郁和功能是依从性的近似标志，依赖患者自我报告或BD症状表现可能会导致服药行为的不完整情况。
■研究纳入标准包括年龄≥18岁，BD1型或2型，药物依从性困难和积极症状，通过简明精神病评定量表（BPRS）评分≥36，年轻躁狂评定量表（YMRS）>8或蒙哥马利·阿斯伯格抑郁评定量表（MADRS）>8。通过2种方式测量依从性：1）自我报告的片剂常规问卷（TRQ）和2）电子药丸容器监测（eCappillbox）。BD症状和功能用MADRS测量，YMRS,临床整体印象量表（CGI），全球功能评估（GAF）。仅检查筛选和基线数据。
■平均年龄42.32(SD=12.99)岁,72.46%(n=50)女性和43.48%(n=30)非白人。在筛查和基线时，使用TRQ错过BD药物治疗的过去7天平均百分比为40.63%(SD=32.61)和30.30%(SD=30.41)。分别。使用eCap的基线依从性为42.16%（SD=35.85），那些有eCap数据的人（n=41）。基于TRQ的较差依从性与较高的MADRS（p=0.04）和CGI（p=0.03）但较低的GAF（p=0.02）显着相关。eCAP测量的依从性与临床变量无显著相关。
■虽然抑郁和功能是依从性的近似标志，依赖患者自我报告或BD症状表现可能会导致服药行为的不完整情况。
