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Abstract：
Ferroptosis, an emerging type of programmed cell death, is initiated by iron-dependent and excessive ROS-mediated lipid peroxidation, which eventually leads to plasma membrane rupture and cell death. Many canonical signalling pathways and biological processes are involved in ferroptosis. Furthermore, cancer cells are more susceptible to ferroptosis due to the high load of ROS and unique metabolic characteristics, including iron requirements. Recent investigations have revealed that ferroptosis plays a crucial role in the progression of tumours, especially HCC. Specifically, the induction of ferroptosis can not only inhibit the growth of hepatoma cells, thereby reversing tumorigenesis, but also improves the efficacy of immunotherapy and enhances the antitumour immune response. Therefore, triggering ferroptosis has become a new therapeutic strategy for cancer therapy. In this review, we summarize the characteristics of ferroptosis based on its underlying mechanism and role in HCC and provide possible therapeutic applications.
摘要：
Ferroptosis,一种新兴的程序性细胞死亡，由铁依赖性和过量的ROS介导的脂质过氧化引发，最终导致质膜破裂和细胞死亡。许多典型的信号传导途径和生物过程参与铁死亡。此外，由于ROS的高负荷和独特的代谢特征，癌细胞更容易发生铁死亡，包括铁的要求。最近的研究表明，铁性凋亡在肿瘤的进展中起着至关重要的作用，尤其是HCC。具体来说,铁凋亡的诱导不仅可以抑制肝癌细胞的生长，从而逆转肿瘤发生，而且还提高了免疫疗法的疗效并增强了抗肿瘤免疫反应。因此,触发铁性凋亡已成为癌症治疗的一种新的治疗策略。在这次审查中,我们根据其在HCC中的潜在机制和作用总结了铁死亡的特征，并提供了可能的治疗应用。
