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Abstract：
Background Connective tissue disorders encompass a diverse array of autoimmune and hereditary conditions, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and antiphospholipid antibody syndrome. These disorders present unique challenges during pregnancy due to their complex pathophysiology and potential complications. Understanding their impact on pregnancy outcomes is vital for optimizing maternal and fetal health. Objective To investigate the burden, complications, maternal and fetal outcomes, and prognosis of connective tissue disorders in pregnancy. Methods The study was conducted over one year and six months at Saveetha Medical College and Hospital, Chennai, India, involving 45 pregnant women diagnosed with connective tissue disorders. Standard antenatal investigations were conducted, and participants were monitored throughout the antenatal period. Maternal and fetal outcomes were meticulously evaluated. Results Baseline characteristics revealed a heterogeneous distribution of age and parity among participants, reflecting the diverse nature of connective tissue disorders in pregnancy. Maternal medical outcomes, such as gestational hypertension (GHTN) and gestational diabetes mellitus (GDM), were prevalent, highlighting the necessity of close monitoring. Obstetric outcomes included spontaneous abortion and preterm delivery, indicating elevated risks in this population. Fetal outcomes, including fetal growth restriction and admission to the neonatal intensive care unit, underscored the impact of these disorders on fetal health. Conclusion This study examines pregnant connective tissue disorder burden, complications, maternal and fetal outcomes, and prognosis. The complicated relationship between these illnesses, and pregnancy requires specialist care and close monitoring. The participants\' baseline features represent connective tissue condition heterogeneity, affecting clinical practice. Among the study subjects, 40% had RA and 20% had SLE, the most common connective tissue illness. Adverse maternal medical outcomes, like GHTN (27.27% of antiphospholipid syndrome (APS) patients and 22.22% of SLE patients) and GDM (18.18% of APS patients and 11.11% of SLE patients), highlight the need for close maternal health monitoring and management during pregnancy. Overall, this study sheds light on connective tissue abnormalities and pregnancy outcomes. Healthcare providers can improve reproductive health and well-being for various illnesses by knowing these relationships.
摘要：
背景结缔组织疾病包括一系列不同的自身免疫和遗传性疾病，包括系统性红斑狼疮（SLE），类风湿性关节炎(RA),和抗磷脂抗体综合征.这些疾病由于其复杂的病理生理学和潜在的并发症而在怀孕期间呈现独特的挑战。了解它们对妊娠结局的影响对于优化孕产妇和胎儿健康至关重要。目的调查负担,并发症,产妇和胎儿的结局，妊娠结缔组织疾病的预后。方法本研究在Saveetha医学院和医院进行了为期一年零六个月的研究。钦奈,印度,涉及45名被诊断患有结缔组织疾病的孕妇。进行了标准的产前调查，参与者在整个产前期间接受监测.精心评估产妇和胎儿的结局。结果基线特征揭示了参与者之间年龄和均等的异质性分布，反映了怀孕期间结缔组织疾病的多样性。孕产妇医疗结果，如妊娠期高血压(GHTN)和妊娠期糖尿病(GDM)，普遍存在，强调密切监测的必要性。产科结果包括自然流产和早产，表明该人群的风险升高。胎儿结局,包括胎儿生长受限和新生儿重症监护病房，强调了这些疾病对胎儿健康的影响。结论本研究检查了妊娠结缔组织疾病负担，并发症,产妇和胎儿的结局，和预后。这些疾病之间的复杂关系，怀孕需要专科护理和密切监测。参与者的基线特征代表结缔组织状况异质性，影响临床实践。在研究对象中，40%患有RA，20%患有SLE，最常见的结缔组织疾病。不良的孕产妇医疗结果，如GHTN（27.27%的抗磷脂综合征（APS）患者和22.22%的SLE患者）和GDM（18.18%的APS患者和11.11%的SLE患者），强调需要在怀孕期间密切监测和管理孕产妇健康。总的来说,这项研究揭示了结缔组织异常和妊娠结局。医疗保健提供者可以通过了解这些关系来改善各种疾病的生殖健康和福祉。
