PDF(Pubmed)
Abstract：
UNASSIGNED: Giardia lamblia is a common intestinal parasite worldwide, mainly in children from low- and middle-income countries (LMIC). Also, it has been associated with increased intestinal permeability, stunting, and cognitive impairment. Nonetheless, the pathogenesis of long-term consequences is difficult to elucidate.
UNASSIGNED: Recent studies try to understand the long-term consequences of Giardia infections. First, well-characterized studies associate Giardia with intestinal damage and child growth. Second, infections appear not to be associated with inflammation, but \"lack of inflammation\" may not, however, entirely exclude a pro-inflammatory pathway. Finally, some important amino acids are lower and could contribute to prolongate stunting and cognitive deficit.
UNASSIGNED: Giardia infections in LMIC used to be associated with child growth shortfalls, gut permeability, and cognitive deficits. Multifactorial effects could be associated with Giardia, including nutritional, altered microbiota, and generation of potentially toxic microbial metabolic byproducts, all together increasing risk of long-term outcomes.
UNASSIGNED: Recent studies try to understand the long-term consequences of Giardia infections. First, well-characterized studies associate Giardia with intestinal damage and child growth. Second, infections appear not to be associated with inflammation, but \"lack of inflammation\" may not, however, entirely exclude a pro-inflammatory pathway. Finally, some important amino acids are lower and could contribute to prolongate stunting and cognitive deficit.
UNASSIGNED: Giardia infections in LMIC used to be associated with child growth shortfalls, gut permeability, and cognitive deficits. Multifactorial effects could be associated with Giardia, including nutritional, altered microbiota, and generation of potentially toxic microbial metabolic byproducts, all together increasing risk of long-term outcomes.
摘要：
■蓝氏贾第鞭毛虫是全球常见的肠道寄生虫，主要来自低收入和中等收入国家（LMIC）的儿童。此外，它与肠道通透性增加有关，发育迟缓,和认知障碍。尽管如此，长期后果的发病机制难以阐明。
■最近的研究试图了解贾第鞭毛虫感染的长期后果。首先,特征明确的研究将贾第鞭毛虫与肠道损伤和儿童生长联系起来。第二,感染似乎与炎症无关，但是“缺乏炎症”可能不会，然而,完全排除了促炎途径。最后,一些重要的氨基酸含量较低，可能会延长发育迟缓和认知缺陷。
■LMIC中的贾第虫感染曾经与儿童生长不足有关，肠道通透性，和认知缺陷。多因素效应可能与贾第虫有关，包括营养,改变了微生物群，产生潜在的有毒微生物代谢副产物，共同增加长期结果的风险。
■最近的研究试图了解贾第鞭毛虫感染的长期后果。首先,特征明确的研究将贾第鞭毛虫与肠道损伤和儿童生长联系起来。第二,感染似乎与炎症无关，但是“缺乏炎症”可能不会，然而,完全排除了促炎途径。最后,一些重要的氨基酸含量较低，可能会延长发育迟缓和认知缺陷。
■LMIC中的贾第虫感染曾经与儿童生长不足有关，肠道通透性，和认知缺陷。多因素效应可能与贾第虫有关，包括营养,改变了微生物群，产生潜在的有毒微生物代谢副产物，共同增加长期结果的风险。
