Abstract：
Fish skin plays an important role in defending against pathogens in water, primarily through the secretion of skin mucus containing various immune-related factors. Local immune responses in the skin activate systemic immune responses by inflammatory cytokines. However, it remains unclear whether immune responses in the skin occur after systemic immune responses caused by pathogen invasion into the fish body. This study aimed to clarify the relationship between systemic immune responses and skin responses after intraperitoneal injection of formalin-killed cells (FKC) of Vibrio anguillarum. Although systemic inflammatory responses were observed in the spleen after injection, expression changes in the skin did not show significant differences. In contrast, expression of hemoglobin subunit genes significantly increased in the skin after FKC injection, suggesting that erythrocytes infiltrate extravascularly.
摘要：
鱼皮在防御水体中的病原体中起着重要的作用，主要通过分泌含有各种免疫相关因子的皮肤粘液。皮肤中的局部免疫应答通过炎性细胞因子激活全身免疫应答。然而,目前尚不清楚病原体入侵鱼体引起的全身免疫反应后，皮肤是否会发生免疫反应。本研究旨在阐明腹膜内注射福尔马林杀死的anguillarum弧菌细胞（FKC）后全身免疫反应与皮肤反应之间的关系。尽管注射后在脾脏中观察到全身性炎症反应，在皮肤中的表达变化没有显着差异。相比之下,FKC注射后，皮肤中血红蛋白亚基基因的表达显着增加，提示红细胞浸润血管外。
