Abstract：
Ankyrin repeat is a 33-amino acid motif commonly observed in eukaryotes and, to a lesser extent, in prokaryotes and archaea and rarely in viruses. This motif plays a crucial role in regulating various cellular processes like the cell cycle, transcription, cell signaling, and inflammatory responses through interactions between proteins. Poxviruses exhibit a distinctive feature of containing multiple ankyrin repeat proteins within their genomes. All the genera of poxviruses possess these proteins except molluscipox virus, crocodylidpox virus, and red squirrel poxvirus. An intriguing characteristic has generated notable interest in studying the functions of these proteins within poxvirus biology. Within poxviruses, ankyrin repeat proteins exhibit a distinct configuration, featuring ankyrin repeats in the N-terminal region and a cellular F-box homolog in the C-terminal region, which enables interactions with the cellular Skp, Cullin, F-box containing ubiquitin ligase complex. Through the examination of experimental evidences and discussions from current literature, this review elucidates the organization and role of ankyrin repeat proteins in poxviruses. Various research studies have highlighted the significant importance of these proteins in poxviral pathogenesis and, acting as factors that enhance virulence. Consequently, they represent viable targets for developing genetically altered viruses with decreased virulence, thus displaying potential as candidates for vaccines and antiviral therapeutic development contributing to safer and more effective strategies against poxviral infections.
摘要：
Ankyrin重复是在真核生物中常见的33个氨基酸基序，在较小程度上，在原核生物和古细菌中，很少在病毒中。这个基序在调节细胞周期等各种细胞过程中起着至关重要的作用，转录,细胞信号，和通过蛋白质之间的相互作用的炎症反应。痘病毒表现出在其基因组中含有多个锚蛋白重复蛋白的独特特征。除软体动物痘病毒外，所有痘病毒属都具有这些蛋白质，crocodylidox病毒,和红松鼠痘病毒.有趣的特征在研究痘病毒生物学中这些蛋白质的功能方面引起了人们的极大兴趣。在痘病毒中，锚蛋白重复蛋白表现出独特的构型，具有N末端区域中的锚蛋白重复和C末端区域中的细胞F盒同源物，这使得与细胞Skp相互作用，Cullin,含F盒的泛素连接酶复合物。通过对实验证据的检验和对现有文献的讨论，本文综述了痘病毒中锚蛋白重复蛋白的组织和作用。各种研究都强调了这些蛋白质在痘病毒发病机理中的重要性，作为增强毒力的因素。因此,它们代表了开发毒力降低的基因改变病毒的可行目标，因此显示出作为疫苗和抗病毒治疗开发候选者的潜力，有助于更安全和更有效的防治痘病毒感染的策略。
