PDF(Pubmed)
Abstract：
BACKGROUND: In recent years, Babesia and Bartonella species co-infections in patients with chronic, nonspecific illnesses have continued to challenge and change the collective medical understanding of \"individual pathogen\" vector-borne infectious disease dynamics, pathogenesis and epidemiology. The objective of this case series is to provide additional molecular documentation of Babesia odocoilei infection in humans in the Americas and to emphasize the potential for co-infection with a Bartonella species.
METHODS: The development of improved and more sensitive molecular diagnostic techniques, as confirmatory methods to assess active infection, has provided increasing clarity to the healthcare community.
RESULTS: Using a combination of different molecular diagnostic approaches, infection with Babesia odocoilei was confirmed in seven people suffering chronic non-specific symptoms, of whom six were co-infected with one or more Bartonella species.
CONCLUSIONS: We conclude that infection with Babesia odocoilei is more frequent than previously documented and can occur in association with co-infection with Bartonella spp.
METHODS: The development of improved and more sensitive molecular diagnostic techniques, as confirmatory methods to assess active infection, has provided increasing clarity to the healthcare community.
RESULTS: Using a combination of different molecular diagnostic approaches, infection with Babesia odocoilei was confirmed in seven people suffering chronic non-specific symptoms, of whom six were co-infected with one or more Bartonella species.
CONCLUSIONS: We conclude that infection with Babesia odocoilei is more frequent than previously documented and can occur in association with co-infection with Bartonella spp.
摘要：
背景：近年来，慢性巴贝虫和巴尔通体共感染，非特异性疾病继续挑战和改变医学对“个体病原体”媒介传播传染病动态的集体理解，发病机制和流行病学。本病例系列的目的是提供美洲人类卵形巴贝虫感染的其他分子文献，并强调与巴尔通体物种共同感染的可能性。
方法：改进和更灵敏的分子诊断技术的发展，作为评估活动性感染的验证性方法，为医疗保健界提供了越来越清晰的信息。
结果：使用不同分子诊断方法的组合，在7名患有慢性非特异性症状的人中证实了奥多科利亚感染，其中6人与一种或多种巴尔通体共同感染。
结论：我们得出的结论是，卵形巴贝虫的感染比以前记录的更频繁，并且可能与巴尔通菌的共同感染有关。
方法：改进和更灵敏的分子诊断技术的发展，作为评估活动性感染的验证性方法，为医疗保健界提供了越来越清晰的信息。
结果：使用不同分子诊断方法的组合，在7名患有慢性非特异性症状的人中证实了奥多科利亚感染，其中6人与一种或多种巴尔通体共同感染。
结论：我们得出的结论是，卵形巴贝虫的感染比以前记录的更频繁，并且可能与巴尔通菌的共同感染有关。
