PDF(Pubmed)
Abstract：
BACKGROUND: The triglyceride-glucose (TyG) index and its combination with obesity indicators can predict cardiovascular diseases (CVD). However, there is limited research on the relationship between changes in the triglyceride glucose-waist height ratio (TyG-WHtR) and CVD. Our study aims to investigate the relationship between the change in the TyG-WHtR and the risk of CVD.
METHODS: Participants were from the China Health and Retirement Longitudinal Study (CHARLS). CVD was defined as self-reporting heart disease and stroke. Participants were divided into three groups based on changes in TyG-WHtR using K-means cluster analysis. Multivariable binary logistic regression analysis was used to examine the association between different groups (based on the change of TyG-WHtR) and CVD. A restricted cubic spline (RCS) regression model was used to explore the potential nonlinear association of the cumulative TyG-WHtR and CVD events.
RESULTS: During follow-up between 2015 and 2020, 623 (18.8%) of 3312 participants developed CVD. After adjusting for various potential confounders, compared to the participants with consistently low and stable TyG-WHtR, the risk of CVD was significantly higher in participants with moderate and increasing TyG-WHtR (OR 1.28, 95%CI 1.01-1.63) and participants with high TyG-WHtR with a slowly increasing trend (OR 1.58, 95%CI 1.16-2.15). Higher levels of cumulative TyG-WHtR were independently associated with a higher risk of CVD events (per SD, OR 1.27, 95%CI 1.12-1.43).
CONCLUSIONS: For middle-aged and older adults, changes in the TyG-WHtR are independently associated with the risk of CVD. Maintaining a favorable TyG index, effective weight management, and a reasonable waist circumference contribute to preventing CVD.
METHODS: Participants were from the China Health and Retirement Longitudinal Study (CHARLS). CVD was defined as self-reporting heart disease and stroke. Participants were divided into three groups based on changes in TyG-WHtR using K-means cluster analysis. Multivariable binary logistic regression analysis was used to examine the association between different groups (based on the change of TyG-WHtR) and CVD. A restricted cubic spline (RCS) regression model was used to explore the potential nonlinear association of the cumulative TyG-WHtR and CVD events.
RESULTS: During follow-up between 2015 and 2020, 623 (18.8%) of 3312 participants developed CVD. After adjusting for various potential confounders, compared to the participants with consistently low and stable TyG-WHtR, the risk of CVD was significantly higher in participants with moderate and increasing TyG-WHtR (OR 1.28, 95%CI 1.01-1.63) and participants with high TyG-WHtR with a slowly increasing trend (OR 1.58, 95%CI 1.16-2.15). Higher levels of cumulative TyG-WHtR were independently associated with a higher risk of CVD events (per SD, OR 1.27, 95%CI 1.12-1.43).
CONCLUSIONS: For middle-aged and older adults, changes in the TyG-WHtR are independently associated with the risk of CVD. Maintaining a favorable TyG index, effective weight management, and a reasonable waist circumference contribute to preventing CVD.
摘要：
背景：甘油三酯-葡萄糖（TyG）指数及其与肥胖指标的组合可以预测心血管疾病（CVD）。然而,关于甘油三酯葡萄糖-腰高比(TyG-WHtR)变化与CVD之间关系的研究有限.我们的研究旨在探讨TyG-WHtR的变化与CVD风险之间的关系。
方法：参与者来自中国健康与退休纵向研究（CHARLS）。CVD被定义为自我报告的心脏病和中风。使用K均值聚类分析，根据TyG-WHtR的变化将参与者分为三组。使用多变量二元逻辑回归分析来检查不同组（基于TyG-WHtR的变化）与CVD之间的关联。使用受限三次样条（RCS）回归模型来探索累积TyG-WHtR和CVD事件的潜在非线性关联。
结果：在2015年至2020年的随访期间，3312名参与者中有623人（18.8%）发生了CVD。在调整了各种潜在的混杂因素后，与一贯低且稳定的TyG-WHTR的参与者相比，在中度和升高的TyG-WHtR(OR1.28,95CI1.01-1.63)的参与者和具有缓慢升高趋势的高TyG-WHtR(OR1.58,95CI1.16-2.15)的参与者中,CVD风险显著较高.较高的累积TyG-WHtR水平与较高的CVD事件风险独立相关(每SD,或1.27，95CI1.12-1.43）。
结论：对于中老年人，TyG-WHtR的变化与CVD风险独立相关.保持良好的TyG指数，有效的体重管理，合理的腰围有助于预防CVD。
方法：参与者来自中国健康与退休纵向研究（CHARLS）。CVD被定义为自我报告的心脏病和中风。使用K均值聚类分析，根据TyG-WHtR的变化将参与者分为三组。使用多变量二元逻辑回归分析来检查不同组（基于TyG-WHtR的变化）与CVD之间的关联。使用受限三次样条（RCS）回归模型来探索累积TyG-WHtR和CVD事件的潜在非线性关联。
结果：在2015年至2020年的随访期间，3312名参与者中有623人（18.8%）发生了CVD。在调整了各种潜在的混杂因素后，与一贯低且稳定的TyG-WHTR的参与者相比，在中度和升高的TyG-WHtR(OR1.28,95CI1.01-1.63)的参与者和具有缓慢升高趋势的高TyG-WHtR(OR1.58,95CI1.16-2.15)的参与者中,CVD风险显著较高.较高的累积TyG-WHtR水平与较高的CVD事件风险独立相关(每SD,或1.27，95CI1.12-1.43）。
结论：对于中老年人，TyG-WHtR的变化与CVD风险独立相关.保持良好的TyG指数，有效的体重管理，合理的腰围有助于预防CVD。
