关键词: Drug delivery Mitochondria Radiotherapy Xerostomia

Mesh : Xerostomia / etiology prevention & control Humans Mitochondria / drug effects radiation effects Head and Neck Neoplasms / radiotherapy Salivary Glands / radiation effects drug effects pathology Radiation Injuries / prevention & control etiology Animals Radiotherapy / adverse effects methods Quality of Life

来  源:   DOI:10.1186/s12885-024-12582-2   PDF(Pubmed)

Abstract:
Radiotherapy in patients with head and neck cancer fairly leads to xerostomia, profoundly affecting their quality of life. With limited effective preventive and therapeutic methods, attention has turned to exploring alternatives. This article outlines how intraglandular injection of mitochondria-boosting agents can serve as a potential strategy to reduce salivary acinar damage. This method can contribute to the thoughtful development of study protocols or medications to reduce radiation-induced salivary glands damage.
摘要:
头颈部癌症患者的放射治疗会导致口干症,深刻地影响着他们的生活质量。有效的预防和治疗方法有限,注意力已经转向探索替代方案。本文概述了线粒体增强剂的颗粒内注射如何作为减少唾液腺泡损伤的潜在策略。这种方法可以有助于研究方案或药物的深思熟虑的发展,以减少辐射引起的唾液腺损伤。
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