METHODS: This study presents a case of aCML that was diagnosed six years after the patient developed eosinophilia. The patient had undergone tests to rule out other primary and secondary diseases, but the eosinophilia remained unexplained. Treatment with corticosteroids and hydroxyurea had proven ineffective. Six years later, the patient experienced an increase in white blood cells, primarily neutrophils. After ruling out other possible diagnoses, a combination of morphologic and molecular genetic findings led to the diagnosis of aCML. The patient responded well to treatment with azacitidine.
CONCLUSIONS: This study summarizes the current state of aCML diagnosis and management and discusses the possible connection between eosinophilia and aCML.
方法:本研究提供一例aCML病例,该病例在患者出现嗜酸性粒细胞增多6年后确诊。病人接受了检查以排除其他原发性和继发性疾病,但嗜酸性粒细胞增多仍无法解释.用皮质类固醇和羟基脲治疗已证明无效。六年后,病人出现了白细胞的增加,主要是中性粒细胞。排除了其他可能的诊断后,形态学和分子遗传学的结合发现导致了aCML的诊断.患者对阿扎胞苷治疗反应良好。
结论:本研究总结了aCML的诊断和治疗现状,并讨论了嗜酸性粒细胞增多和aCML之间的可能联系。