Abstract：
BACKGROUND: Morphological awareness (MA) deficit is strongly associated with Chinese developmental dyslexia (DD). However, little is known about the white matter substrates underlying the MA deficit in Chinese children with DD.
METHODS: In the current study, 34 Chinese children with DD and 42 typical developmental (TD) children were recruited to complete a diffusion magnetic resonance imaging scan and cognitive tests for MA. We conducted linear regression to test the correlation between MA and DTI metrics, the structural abnormalities of the tracts related to MA, and the interaction effect of DTI metrics by group on MA.
RESULTS: First, MA was significant related to the right inferior occipito-frontal fascicle (IFO) and inferior longitudinal fsciculus (ILF), the bilateral thalamo-occipital (T_OCC) and the left arcuate fasciculus (AF); second, compared to TD children, Chinese children with DD had lower axial diffusivity (AD) in the right IFO and T_OCC; third, there were significant interactions between metrics (fractional anisotropy (FA) and radial diffusivity (RD)) of the right IFO and MA in groups. The FA and RD of the right IFO were significantly associated with MA in children with DD but not in TD children.
CONCLUSIONS: In conclusion, compared to TD children, Chinese children with DD had axonal degeneration not only in the ventral tract (the right IFO) but also the visuospatial tract (the right T_OCC) which were associated with their MA deficit. And Chinese MA involved not only the ventral tracts, but also the visuospatial pathway and dorsal tracts.
METHODS: In the current study, 34 Chinese children with DD and 42 typical developmental (TD) children were recruited to complete a diffusion magnetic resonance imaging scan and cognitive tests for MA. We conducted linear regression to test the correlation between MA and DTI metrics, the structural abnormalities of the tracts related to MA, and the interaction effect of DTI metrics by group on MA.
RESULTS: First, MA was significant related to the right inferior occipito-frontal fascicle (IFO) and inferior longitudinal fsciculus (ILF), the bilateral thalamo-occipital (T_OCC) and the left arcuate fasciculus (AF); second, compared to TD children, Chinese children with DD had lower axial diffusivity (AD) in the right IFO and T_OCC; third, there were significant interactions between metrics (fractional anisotropy (FA) and radial diffusivity (RD)) of the right IFO and MA in groups. The FA and RD of the right IFO were significantly associated with MA in children with DD but not in TD children.
CONCLUSIONS: In conclusion, compared to TD children, Chinese children with DD had axonal degeneration not only in the ventral tract (the right IFO) but also the visuospatial tract (the right T_OCC) which were associated with their MA deficit. And Chinese MA involved not only the ventral tracts, but also the visuospatial pathway and dorsal tracts.
摘要：
背景：形态意识（MA）缺陷与中国发展性阅读障碍（DD）密切相关。然而,关于中国DD儿童MA缺陷背后的白质底物知之甚少。
方法：在目前的研究中，招募了34名患有DD的中国儿童和42名典型发育（TD）儿童，以完成MA的扩散磁共振成像扫描和认知测试。我们进行了线性回归来检验MA和DTI指标之间的相关性，与MA相关的束的结构异常，以及分组DTI指标对MA的交互作用。
结果：首先，MA与右枕骨-额叶下束（IFO）和下纵肌（ILF）显著相关，双侧丘脑-枕骨(T_OCC)和左弓状束(AF);第二,与TD儿童相比，中国患有DD的儿童在右IFO和T_OCC中具有较低的轴向扩散系数（AD）；第三，各组中右IFO和MA的度量（各向异性分数（FA）和径向扩散率（RD））之间存在显着相互作用。在DD儿童中，右IFO的FA和RD与MA显着相关，而在TD儿童中没有。
结论：结论：与TD儿童相比，中国DD儿童不仅在腹侧束（右IFO）而且在视觉空间束（右T_OCC）都有轴突变性，这与他们的MA缺陷有关。中国MA不仅涉及腹侧，还有视觉空间通路和背道。
方法：在目前的研究中，招募了34名患有DD的中国儿童和42名典型发育（TD）儿童，以完成MA的扩散磁共振成像扫描和认知测试。我们进行了线性回归来检验MA和DTI指标之间的相关性，与MA相关的束的结构异常，以及分组DTI指标对MA的交互作用。
结果：首先，MA与右枕骨-额叶下束（IFO）和下纵肌（ILF）显著相关，双侧丘脑-枕骨(T_OCC)和左弓状束(AF);第二,与TD儿童相比，中国患有DD的儿童在右IFO和T_OCC中具有较低的轴向扩散系数（AD）；第三，各组中右IFO和MA的度量（各向异性分数（FA）和径向扩散率（RD））之间存在显着相互作用。在DD儿童中，右IFO的FA和RD与MA显着相关，而在TD儿童中没有。
结论：结论：与TD儿童相比，中国DD儿童不仅在腹侧束（右IFO）而且在视觉空间束（右T_OCC）都有轴突变性，这与他们的MA缺陷有关。中国MA不仅涉及腹侧，还有视觉空间通路和背道。
