Abstract：
Epidemiological studies have reported an association between metabolic dysfunction-associated steatotic liver disease (MASLD) and the risk of urolithiasis. However, the magnitude of the risk and whether this risk varies with the severity of MASLD remains uncertain. We performed a meta-analysis of observational studies to quantify the magnitude of the association between MASLD and urolithiasis. We systematically searched PubMed, Scopus, and Web of Science from database inception to March 31, 2024, using predefined keywords to identify relevant observational studies in which imaging methods or survey questionnaires diagnosed MASLD and urolithiasis. Meta-analysis was performed using random-effects modelling. We identified seven cross-sectional studies and one prospective cohort study with aggregate data on 248,936 adults from different countries. MASLD was significantly associated with an increased risk of prevalent urolithiasis (pooled random-effects odds ratio 1.87, 95% CI 1.34-2.60; I2 = 91%). This association remained significant in those studies whose results were adjusted for age, sex, ethnicity, obesity, diabetes, and other potential confounders. There was a positive graded association between the ultrasonographic severity of MASLD and urolithiasis. Meta-analysis of the single prospective cohort study showed that MAFLD was not associated with risk of developing incident urolithiasis (pooled random-effects hazard ratio 1.08, 95% CI 0.90-1.30), although a significant association was reported in men. Sensitivity analyses did not modify these findings. The funnel plot did not reveal any significant publication bias. This updated meta-analysis provides evidence for a significant association between MASLD and the presence of urolithiasis. Whether MASLD is associated with a higher risk of developing incident urolithiasis remains to be established.
摘要：
流行病学研究报道了代谢功能障碍相关的脂肪变性肝病（MASLD）与尿石症的风险之间的关联。然而,风险的大小以及该风险是否随MASLD的严重程度而变化仍不确定.我们对观察性研究进行了荟萃分析，以量化MASLD与尿石症之间的关联程度。我们系统地搜索了PubMed,Scopus,和WebofScience从数据库开始到2024年3月31日，使用预定义的关键字来识别相关的观察性研究，其中成像方法或调查问卷诊断为MASLD和尿石症。使用随机效应模型进行Meta分析。我们确定了7项横断面研究和1项前瞻性队列研究，收集了来自不同国家的248,936名成年人的数据。MASLD与尿石症的患病率增加显著相关(合并随机效应比值比1.87,95%CI1.34-2.60;I2=91%)。在那些根据年龄调整结果的研究中，这种关联仍然很重要，性别,种族,肥胖，糖尿病,和其他潜在的混杂因素。MASLD的超声检查严重程度与尿石症之间呈正分级相关。单前瞻性队列研究的荟萃分析显示，MAFLD与发生尿石症的风险无关（合并随机效应风险比1.08，95％CI0.90-1.30），尽管在男性中报告了显著的关联。敏感性分析没有改变这些发现。漏斗图没有显示任何显著的发表偏倚。此更新的荟萃分析提供了MASLD与尿石症之间存在显着关联的证据。MASLD是否与发生尿石症的高风险相关还有待确定。
