PDF(Pubmed)
Abstract：
OBJECTIVE: In our study, we aimed to characterise adult childhood cancer survivors (ACCS), assess their health issues, gauge health-related quality of life (HRQOL) and evaluate visit satisfaction.
METHODS: Prospective cohort study using data from clinical visits and questionnaires.
METHODS: Interdisciplinary follow-up programme for ACCS based on the long-term follow-up (LTFU) guidelines of the Children\'s Oncology Group and overseen by internists in two Swiss hospitals.
METHODS: ACCS attending our LTFU clinics between April 2017 and January 2022 were eligible.
METHODS: We documented medical history, current health status and assessed HRQOL using Short Form-36 V.2, comparing it with Swiss general population (SGP) norms (T mean=50, SD=10; age stratified). 3 months post visit, a feedback questionnaire was distributed.
RESULTS: Among 102 ACCS (mean age: 32 years (range: 18-62 years), 68% women), 43 had no prior follow-up (36 ACCS>28 years, 7 ACCS≤28 years). A notable 94% had health issues, affecting an average of 6.1 (SD=3.3) organ systems. HRQOL was lower in ACCS>28 years than the SGP>28 years (physical: 44.8 (SD=11.65) vs 49.3 (SD=10.29), p=0.016; mental: 44.4 (SD=13.78) vs 50.53 (SD=9.92), p=0.004). Older ACCS (>28 years) reported inferior physical (44.8 vs 50.1 (SD=9.30), p=0.017) and mental HRQOL (44.4 vs 50.3 (SD=7.20), p=0.009) than younger ACCS. The majority of respondents reported high levels of satisfaction with the consultation, exceeding 90%.
CONCLUSIONS: ACCS attending LTFU clinics face diverse health issues impacting multiple organ systems and exhibit lower HRQOL compared with the SGP. Thus, internist-led LTFU clinics are crucial for optimising follow-up care.
METHODS: Prospective cohort study using data from clinical visits and questionnaires.
METHODS: Interdisciplinary follow-up programme for ACCS based on the long-term follow-up (LTFU) guidelines of the Children\'s Oncology Group and overseen by internists in two Swiss hospitals.
METHODS: ACCS attending our LTFU clinics between April 2017 and January 2022 were eligible.
METHODS: We documented medical history, current health status and assessed HRQOL using Short Form-36 V.2, comparing it with Swiss general population (SGP) norms (T mean=50, SD=10; age stratified). 3 months post visit, a feedback questionnaire was distributed.
RESULTS: Among 102 ACCS (mean age: 32 years (range: 18-62 years), 68% women), 43 had no prior follow-up (36 ACCS>28 years, 7 ACCS≤28 years). A notable 94% had health issues, affecting an average of 6.1 (SD=3.3) organ systems. HRQOL was lower in ACCS>28 years than the SGP>28 years (physical: 44.8 (SD=11.65) vs 49.3 (SD=10.29), p=0.016; mental: 44.4 (SD=13.78) vs 50.53 (SD=9.92), p=0.004). Older ACCS (>28 years) reported inferior physical (44.8 vs 50.1 (SD=9.30), p=0.017) and mental HRQOL (44.4 vs 50.3 (SD=7.20), p=0.009) than younger ACCS. The majority of respondents reported high levels of satisfaction with the consultation, exceeding 90%.
CONCLUSIONS: ACCS attending LTFU clinics face diverse health issues impacting multiple organ systems and exhibit lower HRQOL compared with the SGP. Thus, internist-led LTFU clinics are crucial for optimising follow-up care.
摘要：
目的：在我们的研究中，我们的目标是描述成人儿童癌症幸存者（ACCS），评估他们的健康问题，测量健康相关生活质量（HRQOL）并评估就诊满意度。
方法：使用来自临床访问和问卷调查的数据进行前瞻性队列研究。
方法：ACCS跨学科随访计划基于儿童肿瘤学组的长期随访（LTFU）指南，并由瑞士两家医院的内科医生监督。
方法：在2017年4月至2022年1月期间参加我们的LTFU诊所的ACCS符合资格。
方法：我们记录了病史，当前健康状况并使用ShortForm-36V.2评估HRQOL，将其与瑞士普通人群（SGP）标准（T均值=50，SD=10；年龄分层）进行比较。3个月后访问，分发了反馈问卷。
结果：在102个ACCS中（平均年龄：32岁（范围：18-62岁），68%的女性），43人之前没有随访(36ACCS>28年，7ACCS≤28年)。值得注意的94%有健康问题，影响平均6.1（SD=3.3）个器官系统。ACCS>28年的HRQOL低于SGP>28年的HRQOL（身体：44.8（SD=11.65）vs49.3（SD=10.29），p=0.016；心理：44.4（SD=13.78）vs50.53（SD=9.92），p=0.004)。年龄较大的ACCS（>28岁）报告身体较差（44.8vs50.1（SD=9.30），p=0.017）和精神HRQOL（44.4vs50.3（SD=7.20），p=0.009）比年轻的ACCS。大多数受访者表示对咨询的满意度很高，超过90%。
结论：参加LTFU诊所的ACCS面临影响多器官系统的各种健康问题，与SGP相比，HRQOL较低。因此，内科医生主导的LTFU诊所对于优化后续护理至关重要。
方法：使用来自临床访问和问卷调查的数据进行前瞻性队列研究。
方法：ACCS跨学科随访计划基于儿童肿瘤学组的长期随访（LTFU）指南，并由瑞士两家医院的内科医生监督。
方法：在2017年4月至2022年1月期间参加我们的LTFU诊所的ACCS符合资格。
方法：我们记录了病史，当前健康状况并使用ShortForm-36V.2评估HRQOL，将其与瑞士普通人群（SGP）标准（T均值=50，SD=10；年龄分层）进行比较。3个月后访问，分发了反馈问卷。
结果：在102个ACCS中（平均年龄：32岁（范围：18-62岁），68%的女性），43人之前没有随访(36ACCS>28年，7ACCS≤28年)。值得注意的94%有健康问题，影响平均6.1（SD=3.3）个器官系统。ACCS>28年的HRQOL低于SGP>28年的HRQOL（身体：44.8（SD=11.65）vs49.3（SD=10.29），p=0.016；心理：44.4（SD=13.78）vs50.53（SD=9.92），p=0.004)。年龄较大的ACCS（>28岁）报告身体较差（44.8vs50.1（SD=9.30），p=0.017）和精神HRQOL（44.4vs50.3（SD=7.20），p=0.009）比年轻的ACCS。大多数受访者表示对咨询的满意度很高，超过90%。
结论：参加LTFU诊所的ACCS面临影响多器官系统的各种健康问题，与SGP相比，HRQOL较低。因此，内科医生主导的LTFU诊所对于优化后续护理至关重要。
