Abstract：
UNASSIGNED: To investigate how passive hyperthermia affect the resting-state functional brain activity based on an acute mouse model after heat stress exposure.
UNASSIGNED: Twenty-eight rs-fMRI data of C57BL/6J male mice which weighing about 24 ∼ 29 g and aged 12 ∼ 16 weeks were collected. The mice in the hyperthermia group (HT, 40 °C ± 0.5 °C, 40 min) were subjected to passive hyperthermia before the anesthesia preparation for scanning. While the normal control group (NC) was subjected to normothermia condition (NC, 20 °C ± 2 °C, 40 min). After data preprocessing, we performed independent component analysis (ICA) and region of interested (ROI)-ROI functional connectivity (FC) analyses on the data of both HT (n = 13) and NC (n = 15).
UNASSIGNED: The group ICA analysis showed that the HT and the NC both included 11 intrinsic connectivity networks (ICNs), and can be divided into four types of networks: the cortical network (CN), the subcortical network (SN), the default mode network (DMN), and cerebellar networks. CN and SN belongs to sensorimotor network. Compared with NC, the functional network organization of ICNs in the HT was altered and the overall functional intensity was decreased. Furthermore, 13 ROIs were selected in CN, SN, and DMN for further ROI-ROI FC analysis. The ROI-ROI FC analysis showed that passive hyperthermia exposure significantly reduced the FC strength in the overall brain represented by CN, SN, DMN of mice.
UNASSIGNED: Prolonged exposure to high temperature has a greater impact on the overall perception and cognitive level of mice, which might help understand the relationship between neuronal activities and physiological thermal sensation and regulation as well as behavioral changes.
UNASSIGNED: Twenty-eight rs-fMRI data of C57BL/6J male mice which weighing about 24 ∼ 29 g and aged 12 ∼ 16 weeks were collected. The mice in the hyperthermia group (HT, 40 °C ± 0.5 °C, 40 min) were subjected to passive hyperthermia before the anesthesia preparation for scanning. While the normal control group (NC) was subjected to normothermia condition (NC, 20 °C ± 2 °C, 40 min). After data preprocessing, we performed independent component analysis (ICA) and region of interested (ROI)-ROI functional connectivity (FC) analyses on the data of both HT (n = 13) and NC (n = 15).
UNASSIGNED: The group ICA analysis showed that the HT and the NC both included 11 intrinsic connectivity networks (ICNs), and can be divided into four types of networks: the cortical network (CN), the subcortical network (SN), the default mode network (DMN), and cerebellar networks. CN and SN belongs to sensorimotor network. Compared with NC, the functional network organization of ICNs in the HT was altered and the overall functional intensity was decreased. Furthermore, 13 ROIs were selected in CN, SN, and DMN for further ROI-ROI FC analysis. The ROI-ROI FC analysis showed that passive hyperthermia exposure significantly reduced the FC strength in the overall brain represented by CN, SN, DMN of mice.
UNASSIGNED: Prolonged exposure to high temperature has a greater impact on the overall perception and cognitive level of mice, which might help understand the relationship between neuronal activities and physiological thermal sensation and regulation as well as behavioral changes.
摘要：
■基于热应激暴露后的急性小鼠模型，研究被动热疗如何影响静息状态的功能性脑活动。
■收集体重约24~29g、年龄12~16周龄的C57BL/6J雄性小鼠28只rs-fMRI数据。热疗组的小鼠（HT，40°C±0.5°C,40分钟）在麻醉准备扫描之前进行被动热疗。正常对照组(NC)处于常温状态(NC,20°C±2°C,40分钟）。数据预处理后,我们对HT(n=13)和NC(n=15)的数据进行了独立成分分析(ICA)和感兴趣区域(ROI)-ROI功能连接(FC)分析.
■组ICA分析表明，HT和NC均包含11个固有连接网络（ICN），可以分为四种类型的网络：皮层网络(CN)，皮层下网络（SN），默认模式网络(DMN)，和小脑网络。CN和SN属于感觉运动网络。与NC相比,HT中ICNs的功能网络组织发生改变,总体功能强度降低.此外，在CN中选择了13个ROI，SN,和DMN用于进一步的ROI-ROIFC分析。ROI-ROIFC分析显示被动热疗显著降低了以CN为代表的全脑的FC强度,SN,小鼠的DMN。
■长时间暴露于高温对小鼠的整体感知和认知水平的影响更大，这可能有助于理解神经元活动与生理热感觉和调节以及行为变化之间的关系。
■收集体重约24~29g、年龄12~16周龄的C57BL/6J雄性小鼠28只rs-fMRI数据。热疗组的小鼠（HT，40°C±0.5°C,40分钟）在麻醉准备扫描之前进行被动热疗。正常对照组(NC)处于常温状态(NC,20°C±2°C,40分钟）。数据预处理后,我们对HT(n=13)和NC(n=15)的数据进行了独立成分分析(ICA)和感兴趣区域(ROI)-ROI功能连接(FC)分析.
■组ICA分析表明，HT和NC均包含11个固有连接网络（ICN），可以分为四种类型的网络：皮层网络(CN)，皮层下网络（SN），默认模式网络(DMN)，和小脑网络。CN和SN属于感觉运动网络。与NC相比,HT中ICNs的功能网络组织发生改变,总体功能强度降低.此外，在CN中选择了13个ROI，SN,和DMN用于进一步的ROI-ROIFC分析。ROI-ROIFC分析显示被动热疗显著降低了以CN为代表的全脑的FC强度,SN,小鼠的DMN。
■长时间暴露于高温对小鼠的整体感知和认知水平的影响更大，这可能有助于理解神经元活动与生理热感觉和调节以及行为变化之间的关系。
