Abstract:
Equine fungal keratitis represents a substantial portion of keratitis cases in horses, with fungal involvement identified in approximately half of all infectious keratitis cases. Despite its prevalence, more comprehensive retrospective analyses are needed to better understand this condition. Outcomes vary, with approximately two-thirds of cases achieving complete healing with retained vision, although enucleation is often necessary. Predominant pathogens include Aspergillus and Fusarium, with yeast reported in a minority of cases. Resistance to common antifungal agents among filamentous fungi poses a significant challenge. Advances in diagnostics, including repeat culture and antifungal susceptibility testing, as well as the incorporation of PCR technology, hold promise for improving detection and guiding treatment decisions. Newer antifungals, combination therapies, and innovative modalities such as photodynamic therapy offer hope for improved outcomes. Continued research efforts are essential to further elucidate the epidemiology, pathogenesis, and optimal management strategies for this condition.
摘要:
马真菌性角膜炎占马角膜炎病例的很大一部分,在大约一半的感染性角膜炎病例中发现真菌参与。尽管流行,需要更全面的回顾性分析来更好地了解这种情况.结果各不相同,大约三分之二的病例在保持视力的情况下实现完全愈合,虽然通常需要摘除。主要病原菌包括曲霉和镰刀菌,在少数病例中报道了酵母。丝状真菌对常见抗真菌药物的抗性提出了重大挑战。诊断的进展,包括重复培养和抗真菌药敏试验,以及结合PCR技术,有望改善检测和指导治疗决策。较新的抗真菌药,联合疗法,和创新的方式,如光动力疗法提供了希望改善的结果。持续的研究工作对于进一步阐明流行病学至关重要,发病机制,以及针对这种情况的最优管理策略。