Mesh : Arginine / metabolism Animals Omentum / immunology microbiology Proteobacteria Humans Mice Gastrointestinal Microbiome / immunology T-Lymphocytes, Regulatory / immunology Neoplasms / immunology microbiology

来  源:   DOI:10.1016/j.chom.2024.05.020

Abstract:
The microbiota can impact antitumor immunity, but whether the microbiota regulates omental antitumor immunity remains elusive. In this issue of Cell Host & Microbe, Meza-Perez et al. demonstrated that Proteobacteria consume arginine to increase Treg cell suppressive capacity and inhibit antitumor immune responses, promoting tumor growth in the omentum.
摘要:
微生物群可以影响抗肿瘤免疫,但是微生物群是否调节网膜的抗肿瘤免疫仍然难以捉摸。在本期《细胞宿主和微生物》中,Meza-Perez等人。表明,变形杆菌消耗精氨酸增加Treg细胞抑制能力和抑制抗肿瘤免疫反应,促进网膜中的肿瘤生长。
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