DMF - DMA 催化合成,分子对接,体外 ,在硅设计 ,和结合自由能的新型硫内酰脲衍生物作为抗氧化剂和抗增殖剂靶向 EGFR 酪氨酸激酶和芳香化酶细胞色素 P450 酶的研究。
关键词: Antioxidant Antiproliferative DMFDMA DPPH Free radical Pyrazole Thiohydantoin
Mesh : Humans Antineoplastic Agents / pharmacology chemical synthesis chemistry Cell Proliferation / drug effects Molecular Docking Simulation Antioxidants / pharmacology chemical synthesis chemistry ErbB Receptors / antagonists & inhibitors metabolism Drug Screening Assays, Antitumor Structure-Activity Relationship Molecular Structure Thiohydantoins / pharmacology chemistry chemical synthesis Aromatase / metabolism Dose-Response Relationship, Drug Drug Design Protein Kinase Inhibitors / pharmacology chemical synthesis chemistry Catalysis Biphenyl Compounds / antagonists & inhibitors pharmacology chemistry Cell Line, Tumor Thermodynamics Picrates / antagonists & inhibitors Hydrazines Thioamides
来 源: DOI:10.1016/j.bioorg.2024.107601