Abstract：
UNASSIGNED: For Hiroshima and Nagasaki survivors, it has not been possible to calculate individual doses from the cytogenetic data and compare them with the physically estimated doses. This is because the cytogenetic studies used solid Giemsa staining which only provides the percent of cells bearing at least one stable-type aberration (most of the unstable-type aberrations had already disappeared), and a gamma-ray dose plus a 10-times neutron dose was used to integrate the data for both cities.
UNASSIGNED: To compare the FISH-derived gamma-ray dose with the DS02R1-derived gamma-ray dose after correcting for a contribution of the neutron dose. It was also an attempt to determine if the frequency of stable-type aberrations had remained unchanged after the exposure.
UNASSIGNED: Stable exchange-type aberration data was obtained using the 2-color FISH method from 1,868 atomic bomb survivors in Hiroshima and Nagasaki. The collected frequency was first extended to a genome-equivalent frequency. Then, by using known induction rates of exchange-type aberrations in vitro caused by neutrons and gamma-rays, respectively, and the mean relationship between the neutron and gamma-ray doses in the DS02R1 estimates for the survivors, the gamma-ray effect was estimated from the total yield of translocations.
UNASSIGNED: It was found that over 95% of individual cytogenetic gamma-ray doses fell within the expected range of plus/minus about 1 Gy from the DS02R1 dose and the mean slope for the linear regression was 0.98, which reassures us of the validity of the DS02R1 study.
UNASSIGNED: The present results demonstrate the validity of the individual DS02R1 doses, and that the frequency of stable-type aberrations in blood lymphocytes did not decay over the years, and thus is useful for retrospective dose evaluations of exposures which took place in the distant past.
UNASSIGNED: To compare the FISH-derived gamma-ray dose with the DS02R1-derived gamma-ray dose after correcting for a contribution of the neutron dose. It was also an attempt to determine if the frequency of stable-type aberrations had remained unchanged after the exposure.
UNASSIGNED: Stable exchange-type aberration data was obtained using the 2-color FISH method from 1,868 atomic bomb survivors in Hiroshima and Nagasaki. The collected frequency was first extended to a genome-equivalent frequency. Then, by using known induction rates of exchange-type aberrations in vitro caused by neutrons and gamma-rays, respectively, and the mean relationship between the neutron and gamma-ray doses in the DS02R1 estimates for the survivors, the gamma-ray effect was estimated from the total yield of translocations.
UNASSIGNED: It was found that over 95% of individual cytogenetic gamma-ray doses fell within the expected range of plus/minus about 1 Gy from the DS02R1 dose and the mean slope for the linear regression was 0.98, which reassures us of the validity of the DS02R1 study.
UNASSIGNED: The present results demonstrate the validity of the individual DS02R1 doses, and that the frequency of stable-type aberrations in blood lymphocytes did not decay over the years, and thus is useful for retrospective dose evaluations of exposures which took place in the distant past.
摘要：
■对于广岛和长崎幸存者，目前还无法根据细胞遗传学数据计算个体剂量,并将其与物理估计剂量进行比较.这是因为细胞遗传学研究使用固体Giemsa染色，该染色仅提供至少一种稳定型畸变的细胞百分比（大多数不稳定型畸变已经消失），使用伽马射线剂量加上10倍中子剂量来整合两个城市的数据。
■在校正中子剂量的贡献后，将FISH衍生的伽马射线剂量与DS02R1衍生的伽马射线剂量进行比较。还试图确定暴露后稳定型像差的频率是否保持不变。
■使用2色FISH方法从广岛和长崎的1,868名原子弹幸存者那里获得了稳定的交换型像差数据。首先将收集的频率扩展到基因组等效频率。然后，通过使用已知的由中子和伽马射线引起的体外交换型像差的诱导率，分别,以及DS02R1估算中幸存者的中子和伽马射线剂量之间的平均关系，从易位的总产量中估计γ射线效应.
■发现超过95％的个体细胞遗传学伽马射线剂量落在DS02R1剂量的正/负约1Gy的预期范围内，线性回归的平均斜率为0.98，这确保了我们DS02R1研究的有效性。
■目前的结果证明了单个DS02R1剂量的有效性，血液淋巴细胞中稳定型畸变的频率多年来没有衰减，因此，对于在遥远的过去发生的暴露的回顾性剂量评估是有用的。
■在校正中子剂量的贡献后，将FISH衍生的伽马射线剂量与DS02R1衍生的伽马射线剂量进行比较。还试图确定暴露后稳定型像差的频率是否保持不变。
■使用2色FISH方法从广岛和长崎的1,868名原子弹幸存者那里获得了稳定的交换型像差数据。首先将收集的频率扩展到基因组等效频率。然后，通过使用已知的由中子和伽马射线引起的体外交换型像差的诱导率，分别,以及DS02R1估算中幸存者的中子和伽马射线剂量之间的平均关系，从易位的总产量中估计γ射线效应.
■发现超过95％的个体细胞遗传学伽马射线剂量落在DS02R1剂量的正/负约1Gy的预期范围内，线性回归的平均斜率为0.98，这确保了我们DS02R1研究的有效性。
■目前的结果证明了单个DS02R1剂量的有效性，血液淋巴细胞中稳定型畸变的频率多年来没有衰减，因此，对于在遥远的过去发生的暴露的回顾性剂量评估是有用的。
