UNASSIGNED: To compare the FISH-derived gamma-ray dose with the DS02R1-derived gamma-ray dose after correcting for a contribution of the neutron dose. It was also an attempt to determine if the frequency of stable-type aberrations had remained unchanged after the exposure.
UNASSIGNED: Stable exchange-type aberration data was obtained using the 2-color FISH method from 1,868 atomic bomb survivors in Hiroshima and Nagasaki. The collected frequency was first extended to a genome-equivalent frequency. Then, by using known induction rates of exchange-type aberrations in vitro caused by neutrons and gamma-rays, respectively, and the mean relationship between the neutron and gamma-ray doses in the DS02R1 estimates for the survivors, the gamma-ray effect was estimated from the total yield of translocations.
UNASSIGNED: It was found that over 95% of individual cytogenetic gamma-ray doses fell within the expected range of plus/minus about 1 Gy from the DS02R1 dose and the mean slope for the linear regression was 0.98, which reassures us of the validity of the DS02R1 study.
UNASSIGNED: The present results demonstrate the validity of the individual DS02R1 doses, and that the frequency of stable-type aberrations in blood lymphocytes did not decay over the years, and thus is useful for retrospective dose evaluations of exposures which took place in the distant past.
■在校正中子剂量的贡献后,将FISH衍生的伽马射线剂量与DS02R1衍生的伽马射线剂量进行比较。还试图确定暴露后稳定型像差的频率是否保持不变。
■使用2色FISH方法从广岛和长崎的1,868名原子弹幸存者那里获得了稳定的交换型像差数据。首先将收集的频率扩展到基因组等效频率。然后,通过使用已知的由中子和伽马射线引起的体外交换型像差的诱导率,分别,以及DS02R1估算中幸存者的中子和伽马射线剂量之间的平均关系,从易位的总产量中估计γ射线效应.
■发现超过95%的个体细胞遗传学伽马射线剂量落在DS02R1剂量的正/负约1Gy的预期范围内,线性回归的平均斜率为0.98,这确保了我们DS02R1研究的有效性。
■目前的结果证明了单个DS02R1剂量的有效性,血液淋巴细胞中稳定型畸变的频率多年来没有衰减,因此,对于在遥远的过去发生的暴露的回顾性剂量评估是有用的。