种系 BARD1 变体通过损害 DNA 修复和钙信号传导而易患间皮瘤。
关键词: cancer prevention carcinogenesis gene × environment genetics mesothelioma
Mesh : Humans DNA Repair / genetics Tumor Suppressor Proteins / genetics metabolism Germ-Line Mutation Ubiquitin-Protein Ligases / genetics metabolism Mesothelioma / genetics Genetic Predisposition to Disease Calcium Signaling / genetics Female Male Middle Aged Tumor Suppressor Protein p53 / genetics metabolism Apoptosis / genetics Fibroblasts / metabolism Asbestos / toxicity Genomic Instability
来 源:
DOI:10.1073/pnas.2405231121
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