PDF(Pubmed)
Abstract：
We examined the associations of vegetarianism with metabolic biomarkers using traditional and genetic epidemiology. First, we addressed inconsistencies in self-reported vegetarianism among UK Biobank participants by utilizing data from two dietary surveys to find a cohort of strict European vegetarians (N = 2,312). Vegetarians were matched 1:4 with nonvegetarians for non-genetic association analyses, revealing significant effects of vegetarianism in 15 of 30 biomarkers. Cholesterol measures plus vitamin D were significantly lower in vegetarians, while triglycerides were higher. A genome-wide association study revealed no genome-wide significant (GWS; 5×10-8) associations with vegetarian behavior. We performed genome-wide gene-vegetarianism interaction analyses for the biomarkers, and detected a GWS interaction impacting calcium at rs72952628 (P = 4.47×10-8). rs72952628 is in MMAA, a B12 metabolic pathway gene; B12 has major deficiency potential in vegetarians. Gene-based interaction tests revealed two significant genes, RNF168 in testosterone (P = 1.45×10-6) and DOCK4 in estimated glomerular filtration rate (eGFR) (P = 6.76×10-7), which have previously been associated with testicular and renal traits, respectively. These nutrigenetic findings indicate genotype can modify the associations between vegetarianism and health outcomes.
摘要：
我们使用传统和遗传流行病学检查了素食主义与代谢生物标志物的关联。首先,我们利用来自两项饮食调查的数据发现了一组严格的欧洲素食者(N=2,312),解决了英国生物银行参与者中自我报告的素食主义不一致的问题.素食者与非素食者1：4进行非遗传关联分析，揭示了素食主义在30个生物标志物中的15个中的显著影响。素食者的胆固醇指标加上维生素D明显较低，而甘油三酯更高。全基因组关联研究显示，与素食行为没有全基因组显着关联（GWS；5×10-8）。我们对生物标志物进行了全基因组基因-素食主义相互作用分析，并在rs72952628处检测到影响钙的GWS相互作用（P=4.47×10-8）。rs72952628在MMAA中，B12代谢途径基因;B12在素食者中具有主要的缺乏潜力。基于基因的相互作用测试揭示了两个重要的基因，睾酮中的RNF168(P=1.45×10-6)和估计肾小球滤过率(eGFR)中的DOCK4(P=6.76×10-7),以前与睾丸和肾脏特征有关，分别。这些营养遗传学发现表明基因型可以改变素食主义与健康结果之间的关联。
