PDF(Pubmed)
Abstract：
Cancer is one of the leading causes of death worldwide, with over 10 million fatalities annually. While tumors can be surgically removed and treated with chemotherapy, radiotherapy, immunotherapy, hormonal therapy, or combined therapies, current treatments often result in toxic side effects in normal tissue. Therefore, researchers are actively seeking ways to selectively eliminate cancerous cells, minimizing the toxic side effects in normal tissue. Caseins and its derivatives have shown promising anti-cancer potential, demonstrating antitumor and cytotoxic effects on cells from various tumor types without causing harm to normal cells. Collectively, these data reveals advancements in the study of caseins and their derivative peptides, particularly providing a comprehensive understanding of the molecular mechanism of action in cancer therapy. These mechanisms occur through various signaling pathways, including (i) the increase of interferon-associated STAT1 signaling, (ii) the suppression of stemness-related markers such as CD44, (iii) the attenuation of the STAT3/HIF1-α signaling, (iv) the down-expression of uPAR and PAI-1, (v) the loss of mitochondrial membrane potential and reduced intracellular ATP production, (vi) the increase of caspase-3 activity, and (vii) the suppression of TLR4/NF-кB signaling. Therefore, we conclude that casein could be an effective adjuvant for cancer treatment.
摘要：
癌症是世界范围内导致死亡的主要原因之一,每年有超过1000万人死亡。虽然肿瘤可以手术切除并用化疗治疗，放射治疗,免疫疗法，激素治疗,或联合疗法，目前的治疗通常会导致正常组织的毒副作用。因此,研究人员正在积极寻找选择性消除癌细胞的方法，将正常组织的毒副作用降至最低。酪蛋白及其衍生物已显示出有希望的抗癌潜力，证明抗肿瘤和细胞毒性作用，从各种肿瘤类型的细胞不造成伤害正常细胞。总的来说，这些数据揭示了酪蛋白及其衍生肽研究的进展，特别是提供对癌症治疗中作用的分子机制的全面了解。这些机制通过各种信号通路发生，包括（i）干扰素相关STAT1信号的增加，（ii）抑制干性相关标志物，如CD44，（iii）衰减STAT3/HIF1-α信号，（iv）uPAR和PAI-1的下调表达，（v）线粒体膜电位的丧失和细胞内ATP产生的减少，（vi）caspase-3活性的增加，和(vii)TLR4/NF-κB信号传导的抑制。因此,我们得出的结论是酪蛋白可能是癌症治疗的有效佐剂。
