PDF(Pubmed)
Abstract：
OBJECTIVE: Coenzyme Q10 (CoQ10) or ubiquinone is one of a cell\'s most important electron carriers during oxidative phosphorylation and many other cellular processes. As a strong anti-oxidant with further anti-inflammatory effects CoQ10 is of potential therapeutical value. The aim of this randomized controlled clinical trial was to investigate the effect of topical CoQ10 on early wound healing after recession coverage surgery using the modified coronally advanced tunnel (MCAT) and palatal connective tissue graft (CTG).
METHODS: Thirty patients with buccal gingival recessions were evaluated after being randomly allocated to: 1) MCAT and CTG with topical application of a coenzyme Q10 spray for 21 days or 2) MCAT and CTG with placebo spray. Wound healing was evaluated by the early wound healing index (EHI). Patient-reported pain was analyzed by a 100-mm visual analogue scale (VAS) at day 2, 7, 14 and 21 post-surgically. Mean recession coverage, gain of keratinized tissue and esthetic outcomes were assessed at 6 months.
RESULTS: EHI and pain scores showed no significant differences. Time to recovery defined as VAS<10 mm was shorter in the test group. Mean root coverage after 6 months was 84.62 ± 26.57% and 72.19 ± 26.30% for test and placebo, p=0.052. Complete root coverage was obtained in 9 (60%) test and in 2 (13.3%) placebo patients. Increase in keratinized tissue width and esthetical outcomes were similar for both groups.
CONCLUSIONS: CoQ10 had no significant effect on early wound healing and on mean root coverage after 6 months.
CONCLUSIONS: Early wound healing: in young healthy patients with no inflammatory oral conditions topical CoQ10 does not improve early healing.
METHODS: Thirty patients with buccal gingival recessions were evaluated after being randomly allocated to: 1) MCAT and CTG with topical application of a coenzyme Q10 spray for 21 days or 2) MCAT and CTG with placebo spray. Wound healing was evaluated by the early wound healing index (EHI). Patient-reported pain was analyzed by a 100-mm visual analogue scale (VAS) at day 2, 7, 14 and 21 post-surgically. Mean recession coverage, gain of keratinized tissue and esthetic outcomes were assessed at 6 months.
RESULTS: EHI and pain scores showed no significant differences. Time to recovery defined as VAS<10 mm was shorter in the test group. Mean root coverage after 6 months was 84.62 ± 26.57% and 72.19 ± 26.30% for test and placebo, p=0.052. Complete root coverage was obtained in 9 (60%) test and in 2 (13.3%) placebo patients. Increase in keratinized tissue width and esthetical outcomes were similar for both groups.
CONCLUSIONS: CoQ10 had no significant effect on early wound healing and on mean root coverage after 6 months.
CONCLUSIONS: Early wound healing: in young healthy patients with no inflammatory oral conditions topical CoQ10 does not improve early healing.
摘要：
目的：辅酶Q10（CoQ10）或泛醌是细胞氧化磷酸化和许多其他细胞过程中最重要的电子载体之一。作为具有进一步抗炎作用的强抗氧化剂,CoQ10具有潜在的治疗价值。这项随机对照临床试验的目的是使用改良的冠状推进隧道（MCAT）和pal结缔组织移植物（CTG）研究局部CoQ10对凹陷覆盖手术后早期伤口愈合的影响。
方法：将30例颊侧牙龈凹陷患者随机分配到：1）MCAT和CTG局部应用辅酶Q10喷雾剂21天或2）MCAT和CTG安慰剂喷雾剂。通过早期伤口愈合指数(EHI)评价伤口愈合。在手术后第2、7、14和21天通过100mm视觉模拟评分(VAS)分析患者报告的疼痛。平均衰退覆盖率，在6个月时评估角化组织的增加和美学结局.
结果：EHI和疼痛评分无显著差异。在测试组中,定义为VAS<10mm的恢复时间较短。试验和安慰剂6个月后的平均根覆盖率为84.62±26.57％和72.19±26.30％，p=0.052。在9名（60％）测试和2名（13.3％）安慰剂患者中获得了完全的根覆盖率。两组角化组织宽度的增加和美学结果相似。
结论：CoQ10对早期伤口愈合和6个月后的平均根部覆盖率没有显著影响。
结论：早期伤口愈合：在没有炎症口腔条件的年轻健康患者中，局部CoQ10不能改善早期愈合。
方法：将30例颊侧牙龈凹陷患者随机分配到：1）MCAT和CTG局部应用辅酶Q10喷雾剂21天或2）MCAT和CTG安慰剂喷雾剂。通过早期伤口愈合指数(EHI)评价伤口愈合。在手术后第2、7、14和21天通过100mm视觉模拟评分(VAS)分析患者报告的疼痛。平均衰退覆盖率，在6个月时评估角化组织的增加和美学结局.
结果：EHI和疼痛评分无显著差异。在测试组中,定义为VAS<10mm的恢复时间较短。试验和安慰剂6个月后的平均根覆盖率为84.62±26.57％和72.19±26.30％，p=0.052。在9名（60％）测试和2名（13.3％）安慰剂患者中获得了完全的根覆盖率。两组角化组织宽度的增加和美学结果相似。
结论：CoQ10对早期伤口愈合和6个月后的平均根部覆盖率没有显著影响。
结论：早期伤口愈合：在没有炎症口腔条件的年轻健康患者中，局部CoQ10不能改善早期愈合。
