METHODS: Thirty patients with buccal gingival recessions were evaluated after being randomly allocated to: 1) MCAT and CTG with topical application of a coenzyme Q10 spray for 21 days or 2) MCAT and CTG with placebo spray. Wound healing was evaluated by the early wound healing index (EHI). Patient-reported pain was analyzed by a 100-mm visual analogue scale (VAS) at day 2, 7, 14 and 21 post-surgically. Mean recession coverage, gain of keratinized tissue and esthetic outcomes were assessed at 6 months.
RESULTS: EHI and pain scores showed no significant differences. Time to recovery defined as VAS<10 mm was shorter in the test group. Mean root coverage after 6 months was 84.62 ± 26.57% and 72.19 ± 26.30% for test and placebo, p=0.052. Complete root coverage was obtained in 9 (60%) test and in 2 (13.3%) placebo patients. Increase in keratinized tissue width and esthetical outcomes were similar for both groups.
CONCLUSIONS: CoQ10 had no significant effect on early wound healing and on mean root coverage after 6 months.
CONCLUSIONS: Early wound healing: in young healthy patients with no inflammatory oral conditions topical CoQ10 does not improve early healing.
方法:将30例颊侧牙龈凹陷患者随机分配到:1)MCAT和CTG局部应用辅酶Q10喷雾剂21天或2)MCAT和CTG安慰剂喷雾剂。通过早期伤口愈合指数(EHI)评价伤口愈合。在手术后第2、7、14和21天通过100mm视觉模拟评分(VAS)分析患者报告的疼痛。平均衰退覆盖率,在6个月时评估角化组织的增加和美学结局.
结果:EHI和疼痛评分无显著差异。在测试组中,定义为VAS<10mm的恢复时间较短。试验和安慰剂6个月后的平均根覆盖率为84.62±26.57%和72.19±26.30%,p=0.052。在9名(60%)测试和2名(13.3%)安慰剂患者中获得了完全的根覆盖率。两组角化组织宽度的增加和美学结果相似。
结论:CoQ10对早期伤口愈合和6个月后的平均根部覆盖率没有显著影响。
结论:早期伤口愈合:在没有炎症口腔条件的年轻健康患者中,局部CoQ10不能改善早期愈合。