PDF(Pubmed)
Abstract：
UNASSIGNED: It has been hypothesized that compromised ocular circulation in glaucoma may be concomitant of systemic changes. The purpose of this study is to test whether systemic blood flow pulse waveform patterns differ between individuals with glaucoma (GL), glaucoma suspects (GLS), and normal healthy controls (HC).
UNASSIGNED: The study included 35 bilateral GL, 67 bilateral GLS, 29 individuals with unilateral GL who were considered GLS in the other eye, and 44 healthy controls. Systemic pulsatile blood pressure waveforms were recorded using a finger cuff. A continuous 200 Hz plethysmography recording is made to obtain a pulse waveform. Waveform parameters were extracted using custom software from an average of eight pulse cycles. These were compared between GL, GLS, and HC groups on a per-eye basis, using generalized estimating equation models to account for intereye correlations; and plotted against disease severity by visual field linearized mean deviation (MDlin) and retinal nerve fiber layer thickness (RNFLT).
UNASSIGNED: Averaged blood pressure was significantly lower in the HC group (mean ± standard deviation 91.7 ±11.7 mm Hg) than the GLS (102.4 ± 13.9) or GL (102.8 ± 13.7) groups, with P < 0.0001 (generalized estimating equation regression). Waveform parameters representing vascular resistance were higher in both GLS and GL groups than the HC group; and were correlated with RNFLT and MDlin (P ≤ 0.05).
UNASSIGNED: The shape of the systemic pulsatile waveform differs in individuals with GL/GLS suspects, compared to HC eyes. Blood pressure changes more rapidly in individuals with GL, which suggests higher arterial stiffness.
UNASSIGNED: The study included 35 bilateral GL, 67 bilateral GLS, 29 individuals with unilateral GL who were considered GLS in the other eye, and 44 healthy controls. Systemic pulsatile blood pressure waveforms were recorded using a finger cuff. A continuous 200 Hz plethysmography recording is made to obtain a pulse waveform. Waveform parameters were extracted using custom software from an average of eight pulse cycles. These were compared between GL, GLS, and HC groups on a per-eye basis, using generalized estimating equation models to account for intereye correlations; and plotted against disease severity by visual field linearized mean deviation (MDlin) and retinal nerve fiber layer thickness (RNFLT).
UNASSIGNED: Averaged blood pressure was significantly lower in the HC group (mean ± standard deviation 91.7 ±11.7 mm Hg) than the GLS (102.4 ± 13.9) or GL (102.8 ± 13.7) groups, with P < 0.0001 (generalized estimating equation regression). Waveform parameters representing vascular resistance were higher in both GLS and GL groups than the HC group; and were correlated with RNFLT and MDlin (P ≤ 0.05).
UNASSIGNED: The shape of the systemic pulsatile waveform differs in individuals with GL/GLS suspects, compared to HC eyes. Blood pressure changes more rapidly in individuals with GL, which suggests higher arterial stiffness.
摘要：
■据推测，青光眼的眼部循环受损可能伴随着全身性变化。这项研究的目的是测试系统性血流脉冲波形模式是否在患有青光眼（GL）的个体之间有所不同。青光眼嫌疑人（GLS），和正常健康对照（HC）。
■该研究包括35个双侧GL，67双边GLS，29名单侧GL患者在另一只眼睛被认为是GLS，和44个健康对照。使用指套记录系统脉动血压波形。进行连续的200Hz体积描记术记录以获得脉冲波形。使用定制软件从8个脉冲周期的平均值中提取波形参数。这些在GL之间进行了比较，GLS,和每只眼睛的HC组，使用广义估计方程模型来解释兴趣相关性；并通过视野线性化平均偏差（MDlin）和视网膜神经纤维层厚度（RNFLT）对疾病严重程度进行绘制。
■HC组的平均血压（平均值±标准偏差91.7±11.7mmHg）明显低于GLS（102.4±13.9）或GL（102.8±13.7）组，P<0.0001(广义估计方程回归)。GLS和GL组代表血管阻力的波形参数均高于HC组；并且与RNFLT和MDlin相关（P≤0.05）。
■系统脉动波形的形状在具有GL/GLS嫌疑人的个体中有所不同，与HC眼睛相比。GL患者的血压变化更快，这表明动脉僵硬度较高。
■该研究包括35个双侧GL，67双边GLS，29名单侧GL患者在另一只眼睛被认为是GLS，和44个健康对照。使用指套记录系统脉动血压波形。进行连续的200Hz体积描记术记录以获得脉冲波形。使用定制软件从8个脉冲周期的平均值中提取波形参数。这些在GL之间进行了比较，GLS,和每只眼睛的HC组，使用广义估计方程模型来解释兴趣相关性；并通过视野线性化平均偏差（MDlin）和视网膜神经纤维层厚度（RNFLT）对疾病严重程度进行绘制。
■HC组的平均血压（平均值±标准偏差91.7±11.7mmHg）明显低于GLS（102.4±13.9）或GL（102.8±13.7）组，P<0.0001(广义估计方程回归)。GLS和GL组代表血管阻力的波形参数均高于HC组；并且与RNFLT和MDlin相关（P≤0.05）。
■系统脉动波形的形状在具有GL/GLS嫌疑人的个体中有所不同，与HC眼睛相比。GL患者的血压变化更快，这表明动脉僵硬度较高。
