PDF(Pubmed)
Abstract：
Mycobacterium abscessus pulmonary infections are increasingly problematic, especially for immunocompromised individuals and those with underlying lung conditions. Currently, there is no reliable standardized treatment, underscoring the need for improved preclinical drug testing. We present a simplified immunosuppressed mouse model using only four injections of cyclophosphamide, which allows for sustained M. abscessus lung burden for up to 16 days. This model proved effective for antibiotic efficacy evaluation, as demonstrated with imipenem or amikacin.
摘要：
脓肿分枝杆菌肺部感染越来越成问题，特别是对于免疫功能低下的个体和那些有潜在肺部疾病的人。目前,没有可靠的标准化治疗，强调需要改进临床前药物测试。我们提出了一个简化的免疫抑制小鼠模型，仅使用四次环磷酰胺注射，这允许持续的M.脓肿肺负担长达16天。该模型被证明对抗生素疗效评估有效，用亚胺培南或阿米卡星证明。
