Abstract：
Elastin, a fibrous extracellular matrix (ECM) protein, is the main component of elastic fibers that are involved in tissues\' elasticity and resilience, enabling them to undergo reversible extensibility and to endure repetitive mechanical stress. After wounding, it is challenging to regenerate elastic fibers and biomaterials developed thus far have struggled to induce its biosynthesis. This review provides a comprehensive summary of elastic fibers synthesis at the cellular level and its implications for biomaterial formulation, with a particular focus on dermal substitutes. The review delves into the intricate process of elastogenesis by cells and investigates potential triggers for elastogenesis encompassing elastin-related compounds, ECM components, and other molecules for their potential role in inducing elastin formation. Understanding of the elastogenic processes is essential for developing biomaterials that trigger not only the synthesis of the elastin protein, but also the formation of a functional and branched elastic fiber network.
摘要：
Elastin,纤维细胞外基质（ECM）蛋白，是参与组织弹性和弹性的弹性纤维的主要成分，使它们能够承受可逆的延展性并承受重复的机械应力。受伤后,再生弹性纤维具有挑战性，迄今为止开发的生物材料一直在努力诱导其生物合成。这篇综述全面总结了细胞水平的弹性纤维合成及其对生物材料配方的影响，特别关注真皮替代品。该综述深入研究了细胞弹性生成的复杂过程，并研究了包含弹性蛋白相关化合物的弹性生成的潜在触发因素，ECM组件,和其他分子在诱导弹性蛋白形成中的潜在作用。了解弹性过程对于开发不仅触发弹性蛋白合成的生物材料至关重要，而且还形成了功能性和支化的弹性纤维网络。
