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Abstract：
UNASSIGNED: This study aimed to evaluate and compare postoperative pain (PP) in single-visit nonsurgical endodontic retreatment (SV NSER) with 2% chlorhexidine (CHX), 0.1% octenidine (OCT) with or without ozone, and 5.25% sodium hypochlorite (NaOCl).
UNASSIGNED: In this randomized, parallel, prospective, double-blind, clinical trial, 132 single-rooted, root-filled teeth with symptomatic apical periodontitis (AP) requiring NSER were allocated into six groups randomly (n = 22/group): 2% CHX with NaOCl (CHXH), 2% Ozonated CHX without NaOCl (OCHX), 2% Ozonated CHX with NaOCl (OCHXH), 0.1% OCT with NaOCl (OCTH), 0.1% Ozonated OCT without NaOCl (OOCT), and 0.1% Ozonated OCT with NaOCl (OOCTH). Standard NSER protocol was followed groups were irrigated with 15 ml of ozonated or nonozonated irrigant (CHX/OCT) for 3-5 min with ultrasonic agitation. PP at baseline, after 6, 12, 24, 48 h, and 7 days was recorded using the Visual Analog Scale (VAS). Logistic regression of predictor variables was compared using the Chi-square test. For group-wise and time-wise comparisons, a two-way analysis of variance followed by the post hoc Bonferroni test was carried out.
UNASSIGNED: None of the patient-related variables in logistic regression obtained a statistically significant (P > 0.05) role in PP. The VAS score after 6 h was OCHX (4.72) > OOCT (4.42) > CHXH (4.23) > OCTH (3.95) > OCHXH (3.42) > OOCTH (3.21). OOCTH and OCHXH groups demonstrated statistically significant reductions in VAS scores at various time intervals (P < 0.05).
UNASSIGNED: SV NSER with ozonated OCT, CHX irrigation, and NaOCl resulted in lesser PP at all time intervals, i.e., 6, 12, 24, 48 h, and 7 days in patients with symptomatic AP.
UNASSIGNED: In this randomized, parallel, prospective, double-blind, clinical trial, 132 single-rooted, root-filled teeth with symptomatic apical periodontitis (AP) requiring NSER were allocated into six groups randomly (n = 22/group): 2% CHX with NaOCl (CHXH), 2% Ozonated CHX without NaOCl (OCHX), 2% Ozonated CHX with NaOCl (OCHXH), 0.1% OCT with NaOCl (OCTH), 0.1% Ozonated OCT without NaOCl (OOCT), and 0.1% Ozonated OCT with NaOCl (OOCTH). Standard NSER protocol was followed groups were irrigated with 15 ml of ozonated or nonozonated irrigant (CHX/OCT) for 3-5 min with ultrasonic agitation. PP at baseline, after 6, 12, 24, 48 h, and 7 days was recorded using the Visual Analog Scale (VAS). Logistic regression of predictor variables was compared using the Chi-square test. For group-wise and time-wise comparisons, a two-way analysis of variance followed by the post hoc Bonferroni test was carried out.
UNASSIGNED: None of the patient-related variables in logistic regression obtained a statistically significant (P > 0.05) role in PP. The VAS score after 6 h was OCHX (4.72) > OOCT (4.42) > CHXH (4.23) > OCTH (3.95) > OCHXH (3.42) > OOCTH (3.21). OOCTH and OCHXH groups demonstrated statistically significant reductions in VAS scores at various time intervals (P < 0.05).
UNASSIGNED: SV NSER with ozonated OCT, CHX irrigation, and NaOCl resulted in lesser PP at all time intervals, i.e., 6, 12, 24, 48 h, and 7 days in patients with symptomatic AP.
摘要：
■本研究旨在评估和比较2％氯己定（CHX）单次非手术牙髓再治疗（SVNSER）的术后疼痛（PP），0.1%奥替尼定（OCT），含或不含臭氧，和5.25%次氯酸钠(NaOCl)。
■在这个随机的，平行,prospective,双盲,临床试验,132单根，有症状的根尖周炎（AP）需要NSER的填充牙齿随机分为六组（n=22/组）：2％CHX与NaOCl（CHXH），2%臭氧化CHX，不含NaOCl(OCHX)，2%臭氧化CHX与NaOCl(OCHXH)，含NaOCl(OCTH)的0.1%OCT,0.1%OzonatedOCT,不含NaOCl(OOCT),和0.1%用NaOCl(OOCTH)臭氧化的OCT。遵循标准NSER方案,各组用15ml臭氧化或非臭氧化冲洗液(CHX/OCT)冲洗3-5分钟,同时超声搅拌。基线PP,在6、12、24、48小时后，使用视觉模拟量表（VAS）记录7天。预测变量的Logistic回归比较采用卡方检验。对于分组和时间比较，进行了双向方差分析，然后进行了事后Bonferroni检验。
■在逻辑回归中没有患者相关变量在PP中具有统计学意义（P>0.05）的作用。6h后VAS评分为OCHX(4.72)>OOCT(4.42)>CHXH(4.23)>OCTH(3.95)>OCHXH(3.42)>OOCTH(3.21)。OOCTH和OCHXH组在不同时间间隔显示VAS评分的统计学显著降低(P<0.05)。
■带有臭氧化OCT的SVNSER，CHX灌溉,NaOCl导致所有时间间隔的PP减少，即，6、12、24、48小时，和有症状的AP患者7天。
■在这个随机的，平行,prospective,双盲,临床试验,132单根，有症状的根尖周炎（AP）需要NSER的填充牙齿随机分为六组（n=22/组）：2％CHX与NaOCl（CHXH），2%臭氧化CHX，不含NaOCl(OCHX)，2%臭氧化CHX与NaOCl(OCHXH)，含NaOCl(OCTH)的0.1%OCT,0.1%OzonatedOCT,不含NaOCl(OOCT),和0.1%用NaOCl(OOCTH)臭氧化的OCT。遵循标准NSER方案,各组用15ml臭氧化或非臭氧化冲洗液(CHX/OCT)冲洗3-5分钟,同时超声搅拌。基线PP,在6、12、24、48小时后，使用视觉模拟量表（VAS）记录7天。预测变量的Logistic回归比较采用卡方检验。对于分组和时间比较，进行了双向方差分析，然后进行了事后Bonferroni检验。
■在逻辑回归中没有患者相关变量在PP中具有统计学意义（P>0.05）的作用。6h后VAS评分为OCHX(4.72)>OOCT(4.42)>CHXH(4.23)>OCTH(3.95)>OCHXH(3.42)>OOCTH(3.21)。OOCTH和OCHXH组在不同时间间隔显示VAS评分的统计学显著降低(P<0.05)。
■带有臭氧化OCT的SVNSER，CHX灌溉,NaOCl导致所有时间间隔的PP减少，即，6、12、24、48小时，和有症状的AP患者7天。
