PDF(Pubmed)
Abstract：
UNASSIGNED: Follow-up imaging of gliomas is crucial to look for residual or recurrence and to differentiate them from nontumoral tissue. Positron emission tomography (PET)-magnetic resonance imaging (MRI) is the problem-solving tool in such cases. We investigated the role of dual point contrast (DPC)-enhanced MRI to discriminate tumoral from the nontumoral tissue compared to PET-MRI taken as the gold standard.
UNASSIGNED: The institutional ethics committee approved the study, and consent was obtained from all the patients included in the study. We prospectively did immediate and 75-min delayed contrast MRI in glioma cases who came for follow-up as a part of PET-MRI study in our institute. Subtracted images were obtained using immediate and 75-min delayed contrast images. Color-coded subtracted images were compared with PET-MRI images. 75-min delayed contrast MRI and diffusion-weighted imaging (DWI) images with Gray Scale inversion were compared with PET attenuation-corrected images.
UNASSIGNED: We included 23 PET MRI cases done with different radiotracers in our study. Overall, we found PET-DPC correlation in (20/20 ~ 100%) cases of enhancing tumors. In two cases (DOPA and fluorodeoxyglucose), since they were nonenhancing low-grade gliomas and the other one was melanoma with intrinsic T1 hyperintensity and the DPC technique could not be used. DWI-PET correlated in 17/19 (~89.4%) cases, and perfusion-weighted imaging (PWI)-PET dynamic susceptibility contrast (DSC)/ASL correlated in 14/18 (~77.7%) cases after cases with hemorrhage were excluded.
UNASSIGNED: DPC MRI showed a good correlation with PET MRI in discriminating tumoral from the nontumoral tissue. DPC MRI can act as a potential alternative to PET MRI in peripheral hospitals where PET is not available. However, the DPC technique is limited in low-grade nonenhancing gliomas.
UNASSIGNED: The institutional ethics committee approved the study, and consent was obtained from all the patients included in the study. We prospectively did immediate and 75-min delayed contrast MRI in glioma cases who came for follow-up as a part of PET-MRI study in our institute. Subtracted images were obtained using immediate and 75-min delayed contrast images. Color-coded subtracted images were compared with PET-MRI images. 75-min delayed contrast MRI and diffusion-weighted imaging (DWI) images with Gray Scale inversion were compared with PET attenuation-corrected images.
UNASSIGNED: We included 23 PET MRI cases done with different radiotracers in our study. Overall, we found PET-DPC correlation in (20/20 ~ 100%) cases of enhancing tumors. In two cases (DOPA and fluorodeoxyglucose), since they were nonenhancing low-grade gliomas and the other one was melanoma with intrinsic T1 hyperintensity and the DPC technique could not be used. DWI-PET correlated in 17/19 (~89.4%) cases, and perfusion-weighted imaging (PWI)-PET dynamic susceptibility contrast (DSC)/ASL correlated in 14/18 (~77.7%) cases after cases with hemorrhage were excluded.
UNASSIGNED: DPC MRI showed a good correlation with PET MRI in discriminating tumoral from the nontumoral tissue. DPC MRI can act as a potential alternative to PET MRI in peripheral hospitals where PET is not available. However, the DPC technique is limited in low-grade nonenhancing gliomas.
摘要：
■胶质瘤的随访成像对于寻找残留或复发并将其与非肿瘤组织区分开来至关重要。在这种情况下，正电子发射断层扫描（PET）-磁共振成像（MRI）是解决问题的工具。与作为金标准的PET-MRI相比，我们研究了双点对比（DPC）增强MRI在区分肿瘤与非肿瘤组织中的作用。
■机构伦理委员会批准了这项研究，并获得了纳入研究的所有患者的同意.作为我们研究所PET-MRI研究的一部分，我们前瞻性地对神经胶质瘤病例进行了即时和75分钟延迟对比MRI检查。使用即时和75分钟延迟的对比图像获得了缩小的图像。将颜色编码的减影图像与PET-MRI图像进行比较。将具有灰度反演的75分钟延迟对比MRI和扩散加权成像（DWI）图像与PET衰减校正图像进行比较。
■我们在研究中纳入了23例用不同放射性示踪剂完成的PETMRI病例。总的来说,我们发现PET-DPC在（20/20〜100％）增强肿瘤中具有相关性。在两种情况下（多巴和氟脱氧葡萄糖），因为它们是非增强性低级别胶质瘤,而另一个是具有固有T1高强度的黑色素瘤,因此无法使用DPC技术.DWI-PET在17/19(~89.4%)病例中具有相关性,14/18（〜77.7％）例出血后，灌注加权成像（PWI）-PET动态敏感性对比（DSC）/ASL相关。
■DPCMRI在区分肿瘤和非肿瘤组织方面与PETMRI显示出良好的相关性。DPCMRI可以在没有PET的外围医院中作为PETMRI的潜在替代方案。然而,DPC技术在低级别非增强胶质瘤中受到限制.
■机构伦理委员会批准了这项研究，并获得了纳入研究的所有患者的同意.作为我们研究所PET-MRI研究的一部分，我们前瞻性地对神经胶质瘤病例进行了即时和75分钟延迟对比MRI检查。使用即时和75分钟延迟的对比图像获得了缩小的图像。将颜色编码的减影图像与PET-MRI图像进行比较。将具有灰度反演的75分钟延迟对比MRI和扩散加权成像（DWI）图像与PET衰减校正图像进行比较。
■我们在研究中纳入了23例用不同放射性示踪剂完成的PETMRI病例。总的来说,我们发现PET-DPC在（20/20〜100％）增强肿瘤中具有相关性。在两种情况下（多巴和氟脱氧葡萄糖），因为它们是非增强性低级别胶质瘤,而另一个是具有固有T1高强度的黑色素瘤,因此无法使用DPC技术.DWI-PET在17/19(~89.4%)病例中具有相关性,14/18（〜77.7％）例出血后，灌注加权成像（PWI）-PET动态敏感性对比（DSC）/ASL相关。
■DPCMRI在区分肿瘤和非肿瘤组织方面与PETMRI显示出良好的相关性。DPCMRI可以在没有PET的外围医院中作为PETMRI的潜在替代方案。然而,DPC技术在低级别非增强胶质瘤中受到限制.
