PDF(Pubmed)
Abstract：
Esophageal squamous cell carcinoma (ESCC) is a malignancy with high incidence in China. Due to the lack of effective molecular targets, the prognosis of ESCC patients is poor. It is urgent to explore the pathogenesis of ESCC to identify promising therapeutic targets. Metabolic reprogramming is an emerging hallmark of ESCC, providing a novel perspective for revealing the biological features of ESCC. In the hypoxic and nutrient-limited tumor microenvironment, ESCC cells have to reprogram their metabolic phenotypes to fulfill the demands of bioenergetics, biosynthesis and redox homostasis of ESCC cells. In this review, we summarized the metabolic reprogramming of ESCC cells that involves glucose metabolism, lipid metabolism, and amino acid metabolism and explore how reprogrammed metabolism provokes novel opportunities for biomarkers and potential therapeutic targets of ESCC.
摘要：
食管鳞状细胞癌(ESCC)是我国发病率较高的恶性肿瘤。由于缺乏有效的分子靶标，ESCC患者的预后较差。迫切需要探索ESCC的发病机制以确定有希望的治疗靶标。代谢重编程是ESCC的一个新兴标志，为揭示ESCC的生物学特征提供了新的视角。在缺氧和营养受限的肿瘤微环境中，ESCC细胞必须重新编程其代谢表型以满足生物能量学的需求，ESCC细胞的生物合成和氧化还原稳态。在这次审查中,我们总结了涉及葡萄糖代谢的ESCC细胞的代谢重编程，脂质代谢，和氨基酸代谢，并探讨重编程代谢如何激发ESCC的生物标志物和潜在治疗靶标的新机会。
